In vivo assessment of biodegradable magnesium alloy ureteral stents in a pig model

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In vivo assessment of biodegradable magnesium alloy ureteral stents in a pig model. / Tie, Di; Liu, Huinan; Guan, Renguo et al.

in: Acta Biomaterialia, Jahrgang 116, 15.10.2020, S. 415-425.

Publikation: Beiträge in ZeitschriftenZeitschriftenaufsätzeForschungbegutachtet

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Tie D, Liu H, Guan R, Holt-Torres P, Liu Y, Wang Y et al. In vivo assessment of biodegradable magnesium alloy ureteral stents in a pig model. Acta Biomaterialia. 2020 Okt 15;116:415-425. doi: 10.1016/j.actbio.2020.09.023

Bibtex

@article{cddb682588d44f06870e1e1702ce2007,
title = "In vivo assessment of biodegradable magnesium alloy ureteral stents in a pig model",
abstract = "Today, ureteral stent technology is making progress towards the reduction of complications and patient discomfort. Therefore, magnesium alloys have become excellent candidate materials for manufacturing ureteral stents due to their biodegradability and antibacterial activity. Built on our previous work on biodegradable magnesium alloys, this article reports a semisolid rheo-formed magnesium implant that displays degradability and biocompatibility in vivo, and feasibility as ureteral stents in a pig model. Refined non-dendritic microstructure was observed in the rheo-formed alloy, whose grain size and shape factor were ca. 25.2 μm and ca. 1.56 respectively. Neither post-interventional inflammation nor pathological changes were observed in the urinary system during the implantation period of 14 weeks, and the degradation profile (14 weeks) meets the common requirement for the indwelling time of ureteral stents (8 to 16 weeks). Furthermore, histopathological observation and urinalysis results confirmed that the alloy had significantly higher antibacterial activity than the medical-grade stainless steel control. To our knowledge, this is the first in vivo study of biodegradable magnesium alloy as urinary implants in large animal models. Our results demonstrate that magnesium alloys may be a reasonable option for manufacturing biodegradable ureteral stents.",
keywords = "Biocompatibility, Biodegradable, In vivo, Magnesium alloy, Ureteral stent, Engineering",
author = "Di Tie and Huinan Liu and Renguo Guan and Patricia Holt-Torres and Yili Liu and Yang Wang and Norbert Hort",
year = "2020",
month = oct,
day = "15",
doi = "10.1016/j.actbio.2020.09.023",
language = "English",
volume = "116",
pages = "415--425",
journal = "Acta Biomaterialia",
issn = "1742-7061",
publisher = "Elsevier B.V.",

}

RIS

TY - JOUR

T1 - In vivo assessment of biodegradable magnesium alloy ureteral stents in a pig model

AU - Tie, Di

AU - Liu, Huinan

AU - Guan, Renguo

AU - Holt-Torres, Patricia

AU - Liu, Yili

AU - Wang, Yang

AU - Hort, Norbert

PY - 2020/10/15

Y1 - 2020/10/15

N2 - Today, ureteral stent technology is making progress towards the reduction of complications and patient discomfort. Therefore, magnesium alloys have become excellent candidate materials for manufacturing ureteral stents due to their biodegradability and antibacterial activity. Built on our previous work on biodegradable magnesium alloys, this article reports a semisolid rheo-formed magnesium implant that displays degradability and biocompatibility in vivo, and feasibility as ureteral stents in a pig model. Refined non-dendritic microstructure was observed in the rheo-formed alloy, whose grain size and shape factor were ca. 25.2 μm and ca. 1.56 respectively. Neither post-interventional inflammation nor pathological changes were observed in the urinary system during the implantation period of 14 weeks, and the degradation profile (14 weeks) meets the common requirement for the indwelling time of ureteral stents (8 to 16 weeks). Furthermore, histopathological observation and urinalysis results confirmed that the alloy had significantly higher antibacterial activity than the medical-grade stainless steel control. To our knowledge, this is the first in vivo study of biodegradable magnesium alloy as urinary implants in large animal models. Our results demonstrate that magnesium alloys may be a reasonable option for manufacturing biodegradable ureteral stents.

AB - Today, ureteral stent technology is making progress towards the reduction of complications and patient discomfort. Therefore, magnesium alloys have become excellent candidate materials for manufacturing ureteral stents due to their biodegradability and antibacterial activity. Built on our previous work on biodegradable magnesium alloys, this article reports a semisolid rheo-formed magnesium implant that displays degradability and biocompatibility in vivo, and feasibility as ureteral stents in a pig model. Refined non-dendritic microstructure was observed in the rheo-formed alloy, whose grain size and shape factor were ca. 25.2 μm and ca. 1.56 respectively. Neither post-interventional inflammation nor pathological changes were observed in the urinary system during the implantation period of 14 weeks, and the degradation profile (14 weeks) meets the common requirement for the indwelling time of ureteral stents (8 to 16 weeks). Furthermore, histopathological observation and urinalysis results confirmed that the alloy had significantly higher antibacterial activity than the medical-grade stainless steel control. To our knowledge, this is the first in vivo study of biodegradable magnesium alloy as urinary implants in large animal models. Our results demonstrate that magnesium alloys may be a reasonable option for manufacturing biodegradable ureteral stents.

KW - Biocompatibility

KW - Biodegradable

KW - In vivo

KW - Magnesium alloy

KW - Ureteral stent

KW - Engineering

UR - http://www.scopus.com/inward/record.url?scp=85091813231&partnerID=8YFLogxK

U2 - 10.1016/j.actbio.2020.09.023

DO - 10.1016/j.actbio.2020.09.023

M3 - Journal articles

C2 - 32949824

AN - SCOPUS:85091813231

VL - 116

SP - 415

EP - 425

JO - Acta Biomaterialia

JF - Acta Biomaterialia

SN - 1742-7061

ER -

DOI