In vivo assessment of biodegradable magnesium alloy ureteral stents in a pig model
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In: Acta Biomaterialia, Vol. 116, 15.10.2020, p. 415-425.
Research output: Journal contributions › Journal articles › Research › peer-review
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TY - JOUR
T1 - In vivo assessment of biodegradable magnesium alloy ureteral stents in a pig model
AU - Tie, Di
AU - Liu, Huinan
AU - Guan, Renguo
AU - Holt-Torres, Patricia
AU - Liu, Yili
AU - Wang, Yang
AU - Hort, Norbert
PY - 2020/10/15
Y1 - 2020/10/15
N2 - Today, ureteral stent technology is making progress towards the reduction of complications and patient discomfort. Therefore, magnesium alloys have become excellent candidate materials for manufacturing ureteral stents due to their biodegradability and antibacterial activity. Built on our previous work on biodegradable magnesium alloys, this article reports a semisolid rheo-formed magnesium implant that displays degradability and biocompatibility in vivo, and feasibility as ureteral stents in a pig model. Refined non-dendritic microstructure was observed in the rheo-formed alloy, whose grain size and shape factor were ca. 25.2 μm and ca. 1.56 respectively. Neither post-interventional inflammation nor pathological changes were observed in the urinary system during the implantation period of 14 weeks, and the degradation profile (14 weeks) meets the common requirement for the indwelling time of ureteral stents (8 to 16 weeks). Furthermore, histopathological observation and urinalysis results confirmed that the alloy had significantly higher antibacterial activity than the medical-grade stainless steel control. To our knowledge, this is the first in vivo study of biodegradable magnesium alloy as urinary implants in large animal models. Our results demonstrate that magnesium alloys may be a reasonable option for manufacturing biodegradable ureteral stents.
AB - Today, ureteral stent technology is making progress towards the reduction of complications and patient discomfort. Therefore, magnesium alloys have become excellent candidate materials for manufacturing ureteral stents due to their biodegradability and antibacterial activity. Built on our previous work on biodegradable magnesium alloys, this article reports a semisolid rheo-formed magnesium implant that displays degradability and biocompatibility in vivo, and feasibility as ureteral stents in a pig model. Refined non-dendritic microstructure was observed in the rheo-formed alloy, whose grain size and shape factor were ca. 25.2 μm and ca. 1.56 respectively. Neither post-interventional inflammation nor pathological changes were observed in the urinary system during the implantation period of 14 weeks, and the degradation profile (14 weeks) meets the common requirement for the indwelling time of ureteral stents (8 to 16 weeks). Furthermore, histopathological observation and urinalysis results confirmed that the alloy had significantly higher antibacterial activity than the medical-grade stainless steel control. To our knowledge, this is the first in vivo study of biodegradable magnesium alloy as urinary implants in large animal models. Our results demonstrate that magnesium alloys may be a reasonable option for manufacturing biodegradable ureteral stents.
KW - Biocompatibility
KW - Biodegradable
KW - In vivo
KW - Magnesium alloy
KW - Ureteral stent
KW - Engineering
UR - http://www.scopus.com/inward/record.url?scp=85091813231&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/978043cf-2011-3944-a514-2f9f632b1972/
U2 - 10.1016/j.actbio.2020.09.023
DO - 10.1016/j.actbio.2020.09.023
M3 - Journal articles
C2 - 32949824
AN - SCOPUS:85091813231
VL - 116
SP - 415
EP - 425
JO - Acta Biomaterialia
JF - Acta Biomaterialia
SN - 1742-7061
ER -