The present study examines whether the seductive details effect is mediated by perceptual processing and whether this mediation as well as the direct effect is moderated by multiple moderators. The Aptitude-Treatment-Interaction Design (N = 108) considers prior knowledge and spatial ability as continuous aptitude variables and seductive details (with vs. without) and task condition (cognitive low-loading single vs. cognitive high-loading dual task) as treatment variables. Two separate models of moderated mediation are focused including task condition as a first moderator and prior knowledge or spatial ability as a second moderator. Results show a full mediation by picture fixation duration with a moderating influence of task condition and prior knowledge on the mediator and a moderating influence of task condition and spatial ability on the direct path for learning success. Especially the low capacity learners were affected under cognitive high-loading conditions. A discussion of these results leads to different theoretical and practical implications.