This study tested the idea that faith in intuition (people’s reliance on their intuition when making judgments or decisions) is negatively associated with vaccination attitudes in the U.S. populace. Intuition is an implicit, affective information processing mode based on prior experiences. U.S. citizens have few threatening experiences with vaccines because vaccination coverage for common vaccine-preventable diseases is high in the United States. Experiences with vaccination-side effects, however, are more prevalent. This is likely to shape an intuition that favors refusal over vaccination. Results of multiple regression analyses support this supposition. With increasing faith in intuition, people’s vaccination attitudes become less favorable.