Putting benign by design into practice-novel concepts for green and sustainable pharmacy: Designing green drug derivatives by non-targeted synthesis and screening for biodegradability
Research output: Journal contributions › Journal articles › Research › peer-review
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Putting benign by design into practice-novel concepts for green and sustainable pharmacy : Designing green drug derivatives by non-targeted synthesis and screening for biodegradability. / Leder, Christoph; Rastogi, Tushar; Kümmerer, Klaus.
In: Sustainable Chemistry and Pharmacy, Vol. 2, 01.12.2015, p. 31-36.Research output: Journal contributions › Journal articles › Research › peer-review
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TY - JOUR
T1 - Putting benign by design into practice-novel concepts for green and sustainable pharmacy
T2 - Designing green drug derivatives by non-targeted synthesis and screening for biodegradability
AU - Leder, Christoph
AU - Rastogi, Tushar
AU - Kümmerer, Klaus
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Pharmaceuticals in the environment are an increasing concern, since the improvement of analytical tools has enabled the detection of parent compounds, metabolites and transformation products of a wide range of pharmaceuticals. These micro-pollutants might compromise the water quality and therefore might become a risk for the environment in general and particularly for humans. Major concerns are for example antibiotics. Antibiotics are used to control infections with pathogenic bacteria. Excessive utilization of non-degradable antibiotics by human patients or in farm animals might lead to accumulation in the water compartment and subsequently to the promotion of resistance development when wide areas containing relevant bacteria have sufficient concentrations of active antibiotics leading to a constant selection pressure on the bacteria. Therefore, it would be attractive to develop a new generation of biodegradable antibiotics, which would rapidly disintegrate into innoxious and in the best case inorganic molecules such as water, carbonate, nitrate and alike in sewage treatment plants or surface water. The guiding principle is the "benign by design" concept.
AB - Pharmaceuticals in the environment are an increasing concern, since the improvement of analytical tools has enabled the detection of parent compounds, metabolites and transformation products of a wide range of pharmaceuticals. These micro-pollutants might compromise the water quality and therefore might become a risk for the environment in general and particularly for humans. Major concerns are for example antibiotics. Antibiotics are used to control infections with pathogenic bacteria. Excessive utilization of non-degradable antibiotics by human patients or in farm animals might lead to accumulation in the water compartment and subsequently to the promotion of resistance development when wide areas containing relevant bacteria have sufficient concentrations of active antibiotics leading to a constant selection pressure on the bacteria. Therefore, it would be attractive to develop a new generation of biodegradable antibiotics, which would rapidly disintegrate into innoxious and in the best case inorganic molecules such as water, carbonate, nitrate and alike in sewage treatment plants or surface water. The guiding principle is the "benign by design" concept.
KW - Chemistry
KW - Benign by design
KW - Non-targeted synthesis
KW - Photo-derivatisation
KW - Pharmacy
KW - Chemistry
KW - Green
KW - Sustainable
UR - http://www.scopus.com/inward/record.url?scp=84958170542&partnerID=8YFLogxK
U2 - 10.1016/j.scp.2015.07.001
DO - 10.1016/j.scp.2015.07.001
M3 - Journal articles
VL - 2
SP - 31
EP - 36
JO - Sustainable Chemistry and Pharmacy
JF - Sustainable Chemistry and Pharmacy
SN - 2352-5541
ER -