Research on organizational behavior and occupational health has undergone an “affective revolution” highlighting the crucial role of affective work-related experiences for individuals and organizations (Ashkanasy & Dorris, 2017). In this chapter, we present a process model of work-related affect, stress, and health (see Figure 8.1). We review and integrate organizational stress and affect research, covering cross-sectional and longitudinal studies (i.e., focusing on chronic processes and between-person differences) as well as experience-sampling studies (i.e., focusing on transient processes and within-person variability). We discuss complex relationship patterns and causal pathways, and offer avenues for future research.