We analyze how the coronavirus is fabricated at the interface between science and the public in order to be addressable by political strategies. By means of a content analysis of Christian Drosten's podcasts, we follow (1) how SARS-CoV-2 is constructed in order to be understood by non-scientists, (2) how the specialist becomes a public expert, and (3) how this co-fabrication takes place. This provides insight into the “fabrication” of meaning and of how uncertainty is transformed into knowledge during times of major risk through focusing on the perception of the virus itself. Out of a perspective of speech act theory-informed assemblage thinking, the analysis emphasizes the role of the known-unknown and of the temporality of developments in formatting both virus and expert.