Abstract: Communicating research findings to the public in a clear but engaging manner is challenging, yet central for maximizing their societal impact. This systematic review aimed to derive evidence-based strategies for science communication from experimental studies. Three databases were searched in December 2022. Experimental studies published in English or German were included if they tested the effect of providing written information about science to adults aged 16+ years by assessing the impact on at least one of four domains of science communication aims (understanding and knowledge, attitudes and trust, intention and behavior, engagement). A total of 171 publications were included. Derived strategies include avoiding jargon, carefully structuring texts, including citations and expert sources, being mindful about how and when to indicate conflict or uncertainty in science, using neutral language, and highlighting Open Science principles and replicability. They can be used to communicate science effectively to lay audiences, benefitting the society.