Due to the worldwide outbreak of COVID-19, many strategies and models have been put forward by researchers who intend to control the current situation with the given means. In particular, compartmental models are being used to model and analyze the COVID-19 dynamics of different considered populations as Susceptible, Exposed, Infected and Recovered compartments (SEIR). This study derives control-oriented compartmental models of the pandemic, together with constructive control laws based on the Lyapunov theory. The paper presents the derivation of new vaccination and quarantining strategies, found using compartmental models and design methods from the field of Lyapunov theory. The Lyapunov theory offers the possibility to track desired trajectories, guaran-teeing the stability of the controlled system. Computer simulations aid to demonstrate the efficacy of the results. Stabilizing control laws are obtained and analyzed for multiple variants of the model. The stability, constructivity, and feasibility are proven for each Lyapunov-like function. Obtaining the proof of practical stability for the controlled system, several interesting system properties such as herd immunity are shown. On the basis of a generalized SEIR model and an extended variant with additional Protected and Quarantined compartments, control strategies are conceived by using two fundamental system inputs, vaccination and quarantine, whose influence on the system is a crucial part of the model. Simulation results prove that Lyapunov-based approaches yield effective control of the disease transmission.