Trace Analysis of the Antineoplastics Ifosfamide and Cyclophosphamide in Sewage Water by Two-Step Solid-Phase Extraction and Gas Chromatography Mass Spectrometry

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A sensitive, specific and highly reproducible method for the analysis of the two antineoplastics, ifosfamide and cyclophosphamide, in sewage water at the ppt-level is presented. The method includes a two-step solid-phase extraction (SPE) on C-18 and SiOH material and GC-MS analysis using single ion monitoring (SIM). The method was applied to degradational studies of the two drugs in laboratory-scale sewage treatment plants (LSSTPs) and to quantification in hospital sewage water samples. It was shown that the drugs were not degraded in LSSTPs and that they turned up in hospital sewage water
Original languageEnglish
JournalJournal of Chromatography A
Issue number1-2
Pages (from-to)179-184
Number of pages6
Publication statusPublished - 01.03.1996
Externally publishedYes

    Research areas

  • Chemistry - Solid-phase extration, Waster water, Ifosfamide, Cyclophosphamide