Trace Analysis of the Antineoplastics Ifosfamide and Cyclophosphamide in Sewage Water by Two-Step Solid-Phase Extraction and Gas Chromatography Mass Spectrometry
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Trace Analysis of the Antineoplastics Ifosfamide and Cyclophosphamide in Sewage Water by Two-Step Solid-Phase Extraction and Gas Chromatography Mass Spectrometry. / Steger-Hartmann, Thomas; Kümmerer, Klaus; Schecker, Jörn.
In: Journal of Chromatography A, Vol. 726, No. 1-2, 01.03.1996, p. 179-184.Research output: Journal contributions › Journal articles › Research › peer-review
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TY - JOUR
T1 - Trace Analysis of the Antineoplastics Ifosfamide and Cyclophosphamide in Sewage Water by Two-Step Solid-Phase Extraction and Gas Chromatography Mass Spectrometry
AU - Steger-Hartmann, Thomas
AU - Kümmerer, Klaus
AU - Schecker, Jörn
PY - 1996/3/1
Y1 - 1996/3/1
N2 - A sensitive, specific and highly reproducible method for the analysis of the two antineoplastics, ifosfamide and cyclophosphamide, in sewage water at the ppt-level is presented. The method includes a two-step solid-phase extraction (SPE) on C-18 and SiOH material and GC-MS analysis using single ion monitoring (SIM). The method was applied to degradational studies of the two drugs in laboratory-scale sewage treatment plants (LSSTPs) and to quantification in hospital sewage water samples. It was shown that the drugs were not degraded in LSSTPs and that they turned up in hospital sewage water
AB - A sensitive, specific and highly reproducible method for the analysis of the two antineoplastics, ifosfamide and cyclophosphamide, in sewage water at the ppt-level is presented. The method includes a two-step solid-phase extraction (SPE) on C-18 and SiOH material and GC-MS analysis using single ion monitoring (SIM). The method was applied to degradational studies of the two drugs in laboratory-scale sewage treatment plants (LSSTPs) and to quantification in hospital sewage water samples. It was shown that the drugs were not degraded in LSSTPs and that they turned up in hospital sewage water
KW - Chemistry
KW - Solid-phase extration
KW - Waster water
KW - Ifosfamide
KW - Cyclophosphamide
UR - http://www.scopus.com/inward/record.url?scp=0002837142&partnerID=8YFLogxK
U2 - 10.1016/0021-9673(95)01063-7
DO - 10.1016/0021-9673(95)01063-7
M3 - Journal articles
VL - 726
SP - 179
EP - 184
JO - Journal of Chromatography
JF - Journal of Chromatography
SN - 0021-9673
IS - 1-2
ER -