Simultaneous determination of alkylphenol ethoxylates and their biotransformation products by liquid chromatography/electrospray ionisation tandem mass spectrometry

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Reversed-phase LC-MS/MS is used to determine major estrogenic alkylphenol ethoxylates (APEOs) and their biotransformation products. It allows the simultaneous analysis of eight APEOs, alkylphenoxy carboxylates (APECs) and alkylphenols (APs) in sewage treatment plant (STP) effluents in the same extract after solid-phase enrichment on polymeric Oasis HLB. As precursor ions, [APEO+NH 4] +, [APEC-H] - and [AP-H] - were monitored. Instrumental limits of detection (LOD) were 2-600pg, corresponding to sample concentrations of 0.04-12ngl -1, without correction for overall method recoveries. Matrix-induced signal suppression during electrospray ionisation (ESI) and extraction as well as overall method recoveries were assessed and the suitability of deuterated surrogates as internal standards was evaluated.

Original languageEnglish
JournalJournal of Chromatography A
Volume1035
Issue number1
Pages (from-to)115-122
Number of pages8
ISSN0021-9673
DOIs
Publication statusPublished - 30.04.2004

    Research areas

  • Chemistry
  • alkylphenol ethoxylates, alkylphenoxy carboxylates, nonylphenol, octylphenol, water analysis