With the programme “Subject-related Partnerships with Universities in Developing Countries” the German Academic Exchange Service (DAAD) supports German universities in structure-building cooperation projects with partners in countries of the South. The German-foreign cooperation aims at giving both sides new impulses in teaching and the formation of new structures at the foreign university. Since 2009 the Institute for Environmental and Sustainability Communication at the Leuphana University of Lüneburg has implemented partnership projects with universities in Ecuador and Peru sponsored by the DAAD. The scientific evaluation of the project “Teaching and Learning Sustainability” with the Universidad Técnica del Norte (UTN), Ecuador, shows that the project contributes to the integration of the concept of sustainable development in teaching, research and administration at the UTN and that it opens opportunities for global learning for all participants. However, also challenges of North-South cooperation in higher education become apparent.