Examination of the Biodegradation of the Antineoplastics Cyclophosphamide and Ifosfamide with the Closed Bottle Test (OECD 301 D)

Research output: Journal contributionsJournal articlesResearchpeer-review


Hospital and communal waste water differ with respect to their content of specific chemical substances like disinfectants or medicaments. Some medicaments are metabolized poorly by patients after administration. Antineoplastic substances are supposed to be cancerogen, mutagen and fetotoxic and embryotoxic substances. At the present there is no information available about their behaviour in the environment. Therefore the biodegradation of ifosfamide and cyclophosphamide was investigated by using the Closed Bottle Test (OECD 301 D). Both the structural isomeric antineoplastics were not biodegraded at a concentration of 5 mg/l in the Closed Bottle Test within 28 days (''not readily biodegradable''). A prolongation of the test up to 57 days did not alter the result. Abiotic elimination was neglectible. Cyclophosphamide and ifosfamide were not found toxic against waste water microorganisms. Further investigations about the elimination of ifosfamide and cyclophosphamide in the process of waste water treatment are necessary to get more knowledge about the possible risk connected with these substances
Translated title of the contributionPrüfung des biologischen abbaus der zytostatika cyclophosphamid und ifosfamid mit dem closed bottle test (oecd 301 d)
Original languageEnglish
JournalZentralblatt für Hygiene und Umweltmedizin
Issue number3
Pages (from-to)215-225
Number of pages11
Publication statusPublished - 1996
Externally publishedYes