Examination of the Biodegradation of the Antineoplastics Cyclophosphamide and Ifosfamide with the Closed Bottle Test (OECD 301 D)
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Examination of the Biodegradation of the Antineoplastics Cyclophosphamide and Ifosfamide with the Closed Bottle Test (OECD 301 D). / Kümmerer, Klaus; Steger-Hartmann, Thomas; Baranyai, Annette et al.
In: Zentralblatt für Hygiene und Umweltmedizin, Vol. 198, No. 3, 1996, p. 215-225.Research output: Journal contributions › Journal articles › Research › peer-review
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TY - JOUR
T1 - Examination of the Biodegradation of the Antineoplastics Cyclophosphamide and Ifosfamide with the Closed Bottle Test (OECD 301 D)
AU - Kümmerer, Klaus
AU - Steger-Hartmann, Thomas
AU - Baranyai, Annette
AU - Burhaus, Iris
PY - 1996
Y1 - 1996
N2 - Hospital and communal waste water differ with respect to their content of specific chemical substances like disinfectants or medicaments. Some medicaments are metabolized poorly by patients after administration. Antineoplastic substances are supposed to be cancerogen, mutagen and fetotoxic and embryotoxic substances. At the present there is no information available about their behaviour in the environment. Therefore the biodegradation of ifosfamide and cyclophosphamide was investigated by using the Closed Bottle Test (OECD 301 D). Both the structural isomeric antineoplastics were not biodegraded at a concentration of 5 mg/l in the Closed Bottle Test within 28 days (''not readily biodegradable''). A prolongation of the test up to 57 days did not alter the result. Abiotic elimination was neglectible. Cyclophosphamide and ifosfamide were not found toxic against waste water microorganisms. Further investigations about the elimination of ifosfamide and cyclophosphamide in the process of waste water treatment are necessary to get more knowledge about the possible risk connected with these substances
AB - Hospital and communal waste water differ with respect to their content of specific chemical substances like disinfectants or medicaments. Some medicaments are metabolized poorly by patients after administration. Antineoplastic substances are supposed to be cancerogen, mutagen and fetotoxic and embryotoxic substances. At the present there is no information available about their behaviour in the environment. Therefore the biodegradation of ifosfamide and cyclophosphamide was investigated by using the Closed Bottle Test (OECD 301 D). Both the structural isomeric antineoplastics were not biodegraded at a concentration of 5 mg/l in the Closed Bottle Test within 28 days (''not readily biodegradable''). A prolongation of the test up to 57 days did not alter the result. Abiotic elimination was neglectible. Cyclophosphamide and ifosfamide were not found toxic against waste water microorganisms. Further investigations about the elimination of ifosfamide and cyclophosphamide in the process of waste water treatment are necessary to get more knowledge about the possible risk connected with these substances
KW - Chemistry
UR - http://www.scopus.com/inward/record.url?scp=0030072652&partnerID=8YFLogxK
M3 - Journal articles
VL - 198
SP - 215
EP - 225
JO - Zentralblatt für Hygiene und Umweltmedizin
JF - Zentralblatt für Hygiene und Umweltmedizin
SN - 0934-8859
IS - 3
ER -