Professorship for Sustainable Chemistry and Material Resources
Organisational unit: Section
Organisation profile
RESEARCH AND TEACHING
Chair for Sustainable Chemistry and Material Resources
We research and train in the field of sustainable chemistry and pharmacy.
We focus on environmental questions as well as on sustainable questions going beyond that such as social and ecological aspects in the context of the life cycle of chemical substances and products. This includes the extraction of raw material, its use as well as the fate after its use. We are also interested in the material flow associated with the extraction and use of the raw material. On top of the experimental work and modeling, we also develop concepts as for example Benign by Design intended dissipation.
Our research and teaching is carried out on an intra- and transdisciplinary scale within the Faculty of Sustainability together with national and international co-operations.
Topics
We are interested in environmental affairs and all questions concerning the sustainability within the context of the life cycle of chemicals, starting with the raw material itself and going on to the synthesis, the use to end up with the environmental fate of chemical substances and products after their use. Beyond the chemical substances and products themselves, we are also interested in the associated material flows, especially when it comes to the so-called strategic resources (e. g. phosphate, seldom metals).
We investigate the fate (e. g. identification of relevant sources) in the environment as well as the spread and the behavior of chemicals (e. g. spread, biological and photochemical degradation) in the aquatic environment in the sense of a sustainable water management. This is why we want to record their effects (e. g. genotoxicity, mutagenity, and bacteria toxicity).At present we are focusing on pesticides, pharmaceuticals, textile auxiliary agents and nanoparticles.
Service offers
Examination of (bio)-degradability of chemicals and pharmaceuticals
according to OECD/DIN/ISO and others:
• Closed Bottle-Test (OECD 301 D)
• Manometric Respirometry (OECD 301 F)
• Zahn-Wellens-Test (OECD 302 B)
• Waste water treatment plant simulation (OECD 303 A)
• Water Sediment Test
• Photochemical degradation
• Photocatalytic degradation
• Electro coalugation
• and other
Toxicity
Acute and chronic toxicity in bacteria:
• Luminescent bacteria test with Vibrio fischeri (30 minutes and 20h)
• Growth-inhibition test with Pseudomonas putida (16h) and Vibrio fischeri (20h)
• Growth-inhibition test with Enteroccus faecalis
Genotoxicity:
• Ames-Test with Salmonella typhimurium TA 98/TA 100
• Umu-Test with Salmonella typhimurium TA 1535/ psK 1002
• Mikronucleus-Test with CHO-Cells by FACS-Analysis
• Green Screen-Assay with TK6-cells
Chemical informatics
Structure property relationships
• Calculation of physicochemical properties of molecules
• Calculation of quantum chemical parameters of molecules
• Calculation of toxicity and mutagenicity
• Calculation of the biological degradation
• Calculation of metabolites (mammalia bacteria)
• Targeted design of chemicals and pharmaceuticals
• Support in purchasing decisions
• Product optimization
• REACH
Water flux based reactive mass transport modelling and assessment
• Spatio-temporal analysis of discharge and water quality (R-Statistics, SigmaPlot, ArcGIS)
• Assessment of water quality by combined water quality and quantity indices (WQI, WQQI, WAI)
• Water quality modelling in lakes and reservoirs in 1D, 2D and 3D (LAC, MOHID Water, Ce-qual)
• Catchment modelling of hydrology, erosion and sedimenttransport, phosphorus discharge, pesticides and transformation product discharge (ZIN-Sed, MOHID Land, reservoir models)
• River channel modelling of water, sediment, phosphorus, pesticide and transformation product discharge (ZIN-Sed, MOHID Stream)
• Scenario modelling and assessment
• System analysis and management assessment
• Integrated water ressources management
Analytics
• Liquid chromatography coupled to ion trap mass spectrometry
• HPLC with UV and fluorescence detection
• Gas chromatography coupled to mass spectrometry
• Ion chromatography
- Published
Gremlin fusion products with immunoglobulin Fc domains and their use as antiinflammatories or immunomodulators
Gawaz, M., Müller, I., Leder, C. & Filzmayer, C., 24.05.2012, IPC No. DE 102010052941A1, Deutsches Patent- und Markenamt, 18.11.2010, Priority date 24.05.2012Research output: Patents › Patent
- Published
1002 Pharmacokinetic studies on a novel HBV entry inhibitor Myrcludex B demonstrate HBV-receptor expression in rodents and dogs but not in cynomolgus monkeys
Schieck, A., Meier, A., Alexandrov, A., Leder, C., Romeis, P., Haberkorn, U., Mier, J. W. & Urban, S., 01.04.2010, In: Journal of Hepatology. 51, 1, p. S387 1 p.Research output: Journal contributions › Conference abstract in journal › Research › peer-review
- Published
Bifunctional recombinant protein SDF1-GPVI as a new therapeutic concept for improved regeneration
Ziegler, M., Baumer, Y., Leder, C., Schönberger, T., Elvers, M., Schlosshauer, B. & Gawaz, M., 02.2011, BioStar 2010 - Science in Exchange: Meeting Abstracts. TERMIS, p. 553-554 2 p. (Tissue Engineering Part A; vol. 17, no. 3/4).Research output: Contributions to collected editions/works › Published abstract in conference proceedings › Research › peer-review
- Published
The bispecific SDF1-GPVI fusion protein preserves myocardial function after transient ischemia in mice.
Ziegler, M., Elvers, M., Baumer, Y., Leder, C., Ochmann, C., Schönberger, T., Jürgens, T., Geisler, T., Schlosshauer, B., Lunov, O., Engelhardt, S., Simmet, T. & Gawaz, M., 07.02.2012, In: Circulation. 125, 5, p. 685-696 12 p.Research output: Journal contributions › Journal articles › Research › peer-review
- Published
The recombinant bifunctional protein αCD133–GPVI promotes repair of the infarcted myocardium in mice
Baumer, Y., Leder, C., Ziegler, M., Schönberger, T., Ochmann, C., Perk, A., Degen, H., Schmid-Horch, B., Elvers, M., Münch, G., Ungerer, M., Schlosshauer, B. & Gawaz, M., 06.2012, In: Journal of Thrombosis and Haemostasis . 10, 6, p. 1152-1164 13 p.Research output: Journal contributions › Journal articles › Research › peer-review
- Published
Elution of monomers from three different bonding systems and their antibacterial effect
Polydorou, O., Rogatti, P., Bolek, R., Wolkewitz, M., Kümmerer, K. & Hellwig, E., 07.2013, In: Odontology / the Society of the Nippon Dental University. 101, 2, p. 170-176 7 p.Research output: Journal contributions › Journal articles › Research › peer-review
- Published
Ready biodegradability of trifluoromethylated phenothiazine drugs, structural elucidation of their aquatic transformation products, and identification of environmental risks studied by LC-MS( n ) and QSAR
Trautwein, C. & Kümmerer, K., 09.2012, In: Environmental Science and Pollution Research. 19, 8, p. 3162-3177 16 p.Research output: Journal contributions › Journal articles › Research › peer-review
- Published
Nonylphenol polyethoxylate degradation by means of electrocoagulation and electrochemical Fenton
Martins, A. F., Wilde, M. L., Vasconcelos, T. G. & Henriques, D. M., 15.06.2006, In: Separation and Purification Technology. 50, 2, p. 249-255 7 p.Research output: Journal contributions › Journal articles › Research › peer-review
- Published
Semi-micro reflux procedure for minimization of chloride interference by COD determination.
Martins, A. F., de Jesus, L. E. W., Vendruscolo, N., Vasconcelos, T. G. & Wilde, M. L., 25.01.2008, In: Clean - Soil, Air, Water. 36, 1, p. 66-69 4 p.Research output: Journal contributions › Journal articles › Research › peer-review
- Published
Enhancement of Capsid Gene Expression: Preparing the Human Papillomavirus Type 16 Major Structural Gene L1 for DNA Vaccination Purposes.
Leder, C., Kleinschmidt, J. A., Wiethe, C. & Müller, M., 01.10.2001, In: Journal of Virology. 75, 19, p. 9201-9209 9 p.Research output: Journal contributions › Journal articles › Research › peer-review
- Published
Identification of a heparin-binding motif on adeno-associated virus type 2 capsids
Kern, A., Schmidt, K., Leder, C., Müller, O., Wobus, C. E., Bettinger, K., von der Lieth, C. W., King, J. A. & Kleinschmidt, J. A., 15.10.2003, In: Journal of Virology. 77, 20, p. 11072–11081 10 p.Research output: Journal contributions › Journal articles › Research › peer-review
- Published
Comparison of PSA-specific CD8+ CTL responses and antitumor immunity generated by plasmid DNA vaccines encoding PSA-HSP chimeric proteins
Pavlenko, M., Roos, A-K., Leder, C., Hansson, L. O., Kiessling, R., Levitskaya, E. & Pisa, P., 12.2004, In: Cancer Immunology, Immunotherapy . 53, 12, p. 1085-1092 8 p.Research output: Journal contributions › Journal articles › Research › peer-review
- Published
Plasmid DNA vaccines against cancer. Cytotoxic T-lymphocyte induction against tumor antigens
Pavlenko, M., Leder, C. & Pisa, P., 01.06.2005, In: Expert Review of Vaccines. 4, 3, p. 315-327 13 p.Research output: Journal contributions › Scientific review articles › Research
- Published
Modeling and predicting aquatic aerobic biodegradation: a review from a user’s perspective.
Rücker, C. & Kümmerer, K., 04.2012, In: Green Chemistry . 14, 4, p. 875-887 13 p.Research output: Journal contributions › Scientific review articles › Research
- Published
Water quantity and quality in the Zerafshan river basin - only an upstream riparian problem?
Olsson, O., Wegerich, K. & Kabilov, F., 01.06.2012, In: International Journal of Water Resources Development. 28, 3, p. 493-505 13 p.Research output: Journal contributions › Journal articles › Research
- Published
Captopril and its dimer captopril disulfide: Photodegradation, aerobic biodegradation and identification of transformation products by HPLC-UV and LC-ion trap-MS(n)
Mahmoud, W. M. M. & Kümmerer, K., 01.08.2012, In: Chemosphere. 88, 10, p. 1170-1177 8 p.Research output: Journal contributions › Journal articles › Research › peer-review
- Published
Approach for detecting mutagenicity of biodegraded and ozonated pharmaceuticals, metabolites and transformation products from a drinking water perspective
Gartiser, S., Hafner, C., Kronenberger-Schäfer, K., Happel, O., Trautwein, C. & Kümmerer, K., 09.2012, In: Environmental Science and Pollution Research. 19, 8, p. 3597-3609 13 p.Research output: Journal contributions › Journal articles › Research › peer-review
- Published
Do edible oils reduce bacterial colonization of enamel in situ ?
Hannig, C., Kirsch, J., Al-Ahmad, A., Kensche, A., Hannig, M. & Kümmerer, K., 03.2013, In: Clinical Oral Investigations. 17, 2, p. 649-658 10 p.Research output: Journal contributions › Journal articles › Research › peer-review
- Published
Priming of CD8+ T-cell responses after DNA immunization is impaired in TLR9- and MyD88-deficient mice.
Pavlenko, M., Leder, C., Moreno, S., Levitsky, V. & Pisa, P., 21.08.2007, In: Vaccine. 25, 34, p. 6341-6347 7 p.Research output: Journal contributions › Journal articles › Research › peer-review
- Published
Modulation of T-effector function by imatinib at the level of cytokine secretion
Leder, C., Ortler, S., Seggewiss, R., Einsele, H. & Wiendl, H., 01.08.2007, In: Experimental Hematology . 35, 8, p. 1266-1271 6 p.Research output: Journal contributions › Journal articles › Research › peer-review
- Published
High performance liquid chromatographic determination of etofibrate and its hydrolysis products.
El-Gindy, A., Hadad, G. M. & Mahmoud, W. M. M., 04.01.2007, In: Journal of Pharmaceutical and Biomedical Analysis. 43, 1, p. 196–203 8 p.Research output: Journal contributions › Journal articles › Research › peer-review
- Published
Optimization and validation of an HPLC-UV method for determination of tranexamic acid in a dosage form and in human urine.
Hadad, G. M., El-Gindy, A. & Mahmoud, W. M. M., 09.2007, In: Chromatographia. 66, 5-6, p. 311-317 7 p.Research output: Journal contributions › Journal articles › Research › peer-review
- Published
Nachhaltiges Ressourcen- und Stoffstrommanagement: Zwischen Gigatonnen und Mikrogramm
Bringezu, S. & Kümmerer, K., 03.2012, In: GAIA. 21, 1, p. 69–72 4 p.Research output: Journal contributions › Journal articles › Research › peer-review
- Published
Trends for snow cover and river flows in the Pamirs (Central Asia)
Chevallier, P., Pouyaud, B., Moja¨ısky, M., Bolgov, M., Olsson, O., Bauer, M. & Froebrich, J., 03.01.2012, In: Hydrology and Earth Systems Sciences Discussion. 9, p. 29–64 36 p.Research output: Journal contributions › Journal articles › Research › peer-review
- Published
Identifizierung und Bewertung ausgewählter Arzneimittel und ihrer Metaboliten (Ab- und Umbauprodukte) im Wasserkreislauf
Kümmerer, K., Schuster, A., Längin, A., Happel, O., Thoma, A., Schneider, K., Hassauer, M., Gartiser, S. & Hafner, C., 01.08.2011, Dessau-Roßlau: Umweltbundesamt, 195 p. (Texte; vol. 46/2011).Research output: Working paper › Project reports › Transfer
- Published
Der Übergang ins Postfossile Zeitalter- Übersehene Knappheiten
Kümmerer, K., 01.2012, In: Tutzinger Blätter. B 13829, 1, p. 13-14 2 p.Research output: Journal contributions › Journal articles › Research
- Published
Dynamische Modellierung der Sorption von Substanzen in einem hydrologischen Einzugsgebietsmodell anhand des Beispiels Phosphor
Gassmann, M. & Olsson, O., 22.03.2012, Wasser ohne Grenzen: Beiträge zum Tag der Hydrologie am 22./23. März 2012 an der Albert-Ludwigs-Universität Freiburg. Weiler, M. (ed.). 1 ed. Deutsche Vereinigung für Wasserwirtschaft, Abwasser und Abfall, 6 p. (Forum für Hydrologie und Wasserbewirtschaftung; vol. 31.12).Research output: Contributions to collected editions/works › Article in conference proceedings › Research
- Published
Stand der Technik und fortschrittliche Ansätze in der Entsorgung des Flowback
Rosenwinkel, K-H., Weichgrebe, D. & Olsson, O., 07.03.2012, BerlinResearch output: other publications › Slides › Research
- Published
Environmental impacts of droughts: key challenges.
Olsson, O., 23.02.2010, BrüsselResearch output: other publications › Slides › Research
- Published
Enhanced reservoir operation as an instrument for supporting water stress mitigation: the Italian case study.
Bauer, M., Botti, P., Zaccolo, S. & Olsson, O., 10.06.2009, The Use of Economic Valuation in Environmental Policy: Providing Research Support for the Implementation of EU Water Policy Under Aquastress. Koundouri, P. (ed.). 1 ed. London: Routledge Taylor & Francis Group, p. 196-220 25 p. (Routledge explorations in environmental economics; no. 17).Research output: Contributions to collected editions/works › Chapter › peer-review
- Published
Analyses of Drugs and Pharmaceuticals in the Environment
Ali, I., Aboul-Enein, H. Y. & Kümmerer, K., 05.07.2011, Biophysico-Chemical Processes of Anthropogenic Organic Compounds in Environmental Systems. Xing, B., Senesi, N. & Ming, P. (eds.). 1 ed. John Wiley & Sons Inc., p. 439-462 24 p.Research output: Contributions to collected editions/works › Chapter › peer-review
- Published
A gene marker panel covering the Wnt and the Ras-Raf-MEK-MAPK signalling pathways allows to detect gene mutations in 80% of early (UICC I) colon cancer stages in humans
Scholtka, B., Schneider, M., Melcher, R., Katzenberger, T., Friedrich, D., Berghof-Jäger, K., Scheppach, W. & Steinberg, P., 08.2009, In: Cancer Epidemiology. 33, 2, p. 123-129 7 p.Research output: Journal contributions › Journal articles › Research › peer-review
- Published
HPLC and chemometrics-assisted UV-spectroscopy methods for the simultaneous determination of ambroxol and doxycycline in capsule.
Hadad, G. M., El-Gindy, A. & Mahmoud, W. M. M., 08.2008, In: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 70, 3, p. 655-663 9 p.Research output: Journal contributions › Journal articles › Research
- Published
Emerging Contaminants versus Micro-pollutants
Kümmerer, K., 10.2011, In: Clean - Soil, Air, Water. 39, 10, p. 889–890 2 p.Research output: Journal contributions › Comments / Debate / Reports › Research
- Published
Antibiotics in the Aquatic Environment
Kümmerer, K., 07.12.2011, Antimicrobial Resistance in the Environment. Keen, P. & Montforts, M. (eds.). 1. ed. Hoboken: John Wiley & Sons Ltd., p. 325-335 11 p.Research output: Contributions to collected editions/works › Chapter › peer-review
- Published
Nonylphenol polyethoxylate in hospital wastewater: A study of the subproducts of electrocoagulation
Henriques, D. M., Kümmerer, K., Mayer, F. M., Vasconcelos, T. G. & Martins, A. F., 01.02.2012, In: Journal of Environmental Science and Health, Part A. Toxic/Hazardous Substances and Environmental Engineering. 47, 3, p. 497-505 9 p.Research output: Journal contributions › Journal articles › Research › peer-review
- Published
Degradation of the tricyclic antipsychotic drug chlorpromazine under environmental conditions, identification of its main aquatic biotic and abiotic transformation products by LC-MS n and their effects on environmental bacteria
Trautwein, C. & Kümmerer, K., 15.03.2012, In: Journal of Chromatography B. 889-890, p. 24-38 15 p.Research output: Journal contributions › Journal articles › Research › peer-review
- Published
Consequences of nuclear accidents for biodiversity and ecosystem services
von Wehrden, H., Fischer, J., Brandt, P., Wagner, V., Kümmerer, K., Kuemmerle, T., Nagel, A., Olsson, O. & Hostert, P., 01.04.2012, In: Conservation Letters. 5, 2, p. 81-89 9 p.Research output: Journal contributions › Scientific review articles › Research
- Published
Chemische Stoffe in der Umwelt
Kümmerer, K. & Ruck, W., 2014, Nachhaltigkeitswissenschaften. Heinrichs, H. & Michelsen, G. (eds.). Berlin, Heidelberg: Springer Spektrum, p. 175-211 27 p.Research output: Contributions to collected editions/works › Contributions to collected editions/anthologies › Education › peer-review
- Published
Photodegradation, Photocatalytic and Aerobic Biodegradation of Sulfisomidine and Identification of Transformation Products By LC–UV-MS/MS
Sleman, F., Mahmoud, W. M. M., Schubert, R. & Kümmerer, K., 11.2012, In: Clean - Soil, Air, Water. 40, 11, p. 1244-1249 6 p.Research output: Journal contributions › Journal articles › Research › peer-review
- Published
The use of a monolithic column to improve the simultaneous determination of caffeine, paracetamol, pseudoephedrine, aspirin, dextromethorphan, chlorpheniramine in pharmaceutical formulations by HPLC-A comparison with a conventional reversed-phase silica-based column
Hadad, G. M. & Mahmoud, W. M. M., 01.12.2011, In: Journal of Liquid Chromatography and Related Technologies. 34, 20, p. 2516–2532 17 p.Research output: Journal contributions › Journal articles › Research › peer-review
- Published
Release of monomers from four different composite materials after halogen and LED curing
Polydorou, O., König, A., Altenburger, M. J., Wolkewitz, M., Hellwig, E. & Kümmerer, K., 01.10.2011, In: American Journal of Dentistry. 24, 5, p. 315-321 7 p.Research output: Journal contributions › Journal articles › Research › peer-review
- Published
Genotoxic effect of ciprofloxacin during photolytic decomposition monitored by the in vitro micronucleus test (MNvit) in HepG2 cells
Garcia-Käufer, M., Bergheim, M., Gminski, R., Gupta, P., Mathur, N., Kümmerer, K., Mersch-Sundermann, V. & Haddad, T., 06.2012, In: Environmental Science and Pollution Research. 19, 5, p. 1719-1727 9 p.Research output: Journal contributions › Journal articles › Research › peer-review
- Published
Assessment of pharmaceutical waste management at selected hospitals and homes in Ghana
Sasu, S., Kümmerer, K. & Kranert, M., 06.2012, In: Waste Management & Research. 30, 6, p. 625-630 6 p.Research output: Journal contributions › Journal articles › Research › peer-review
- Published
Transformation products of pharmaceuticals in surface waters and wastewater formed during photolysis and advanced oxidation processes: Degradation, elucidation of byproducts and assessment of their biological potency
Fatta-Kassinos, D., Vasquez, M. & Kümmerer, K., 10.2011, In: Chemosphere. 85, 5, p. 693-709 17 p.Research output: Journal contributions › Scientific review articles › Research
- Published
Biodegradability and ecotoxicitiy of tramadol, ranitidine, and their photoderivatives in the aquatic environment: Biologische Abbaubarkeit und Ökotoxizität von Tramadol, Ranitidin sowie ihren Photoderivate in der aquatischen Umwelt
Bergheim, M., Gieré, R. & Kümmerer, K., 01.2012, In: Environmental Science and Pollution Research. 19, 1, p. 72-85 14 p.Research output: Journal contributions › Journal articles › Research › peer-review
- Published
Incomplete aerobic degradation of the antidiabetic drug Metformin and identification of the bacterial dead-end transformation product Guanylurea
Trautwein, C. & Kümmerer, K., 10.2011, In: Chemosphere. 85, 5, p. 765-773 9 p.Research output: Journal contributions › Journal articles › Research › peer-review
- Published
A modified epitope identified for generation and monitoring of PSA-specific T cells in patients on early phases of PSA-based immunotherapeutic protocols
Lundberg, K., Roos, A-K., Pavlenko, M., Leder, C., Wehrum, D., Guevara-Patiño, J., Andersen, R. S. & Pisa, P., 04.03.2009, In: Vaccine. 27, 10, p. 1557-1565 9 p.Research output: Journal contributions › Journal articles › Research › peer-review
- Published
Development and validation of a stability-indicating RP-HPLC method for the determination of paracetamol with dantrolene or/and cetirizine and pseudoephedrine in two pharmaceutical dosage forms
Hadad, G. M., Emara, S. & Mahmoud, W. M. M., 15.10.2009, In: Talanta. 79, 5, p. 1360-1367 8 p.Research output: Journal contributions › Journal articles › Research › peer-review
- Published
Biomonitoring Hospital Effluents by the Allium cepa L. Test
Bagatini, M. D., Vasconcelos, T. G., Laughinghouse IV, H. D. & Martins, A. F., 05.2009, In: Bulletin of Environmental Contamination and Toxicology. 82, 5, p. 590-592 3 p.Research output: Journal contributions › Journal articles › Research › peer-review