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Unchanged food approach-avoidance behaviour of healthy men after oxytocin administration

Research output: Journal contributions › Journal articles › Research › peer-review

Standard

Unchanged food approach-avoidance behaviour of healthy men after oxytocin administration. / Melkonyan, Anna; Liu, Lu; Brown, Elliot C et al.
In: Journal of Neuroendocrinology, Vol. 32, No. 12, e12923, 01.12.2020.

Research output: Journal contributions › Journal articles › Research › peer-review

Harvard

Melkonyan, A, Liu, L, Brown, EC, Meyer, W, Madipakkam, AR, Kalon, L, Lange, F, Schmid, SM, Münte, TF & Park, SQ 2020, 'Unchanged food approach-avoidance behaviour of healthy men after oxytocin administration', Journal of Neuroendocrinology, vol. 32, no. 12, e12923. https://doi.org/10.1111/jne.12923

APA

Melkonyan, A., Liu, L., Brown, E. C., Meyer, W., Madipakkam, A. R., Kalon, L., Lange, F., Schmid, S. M., Münte, T. F., & Park, S. Q. (2020). Unchanged food approach-avoidance behaviour of healthy men after oxytocin administration. Journal of Neuroendocrinology, 32(12), Article e12923. https://doi.org/10.1111/jne.12923

Vancouver

Melkonyan A, Liu L, Brown EC, Meyer W, Madipakkam AR, Kalon L et al. Unchanged food approach-avoidance behaviour of healthy men after oxytocin administration. Journal of Neuroendocrinology. 2020 Dec 1;32(12):e12923. doi: 10.1111/jne.12923

Bibtex

@article{a404d71d535d45c8a182a981fc6d3ad3,
title = "Unchanged food approach-avoidance behaviour of healthy men after oxytocin administration",
abstract = "The oxytocinergic system has been assumed to contribute to food intake, possibly via interactions with dopamine. However, so far, it is unknown whether oxytocin influences the underlying motivational behaviour towards food. In the present study, we used a food-based approach-avoidance task (AAT) in a randomised, placebo-controlled, double-blind, cross-over design to compare intranasal oxytocin with a placebo. In the AAT, participants pushed or pulled a joystick when images of foods with a high or low craving rating were presented, where differences in response times typically reflect approach and avoidance motivational biases towards positively and negatively valence stimuli, respectively. Thirty-three healthy male participants (age = 25.12 ± 3.51 years; body mass index = 24.25 ± 2.48 kg/m2 ) completed the two-session study, one with placebo and the other with oxytocin. We used mixed-effects models to investigate effects of treatment (oxytocin, placebo), response type (approach, avoid) and stimulus (high, low craving). The results showed that both approach and avoid responses tended to be faster for foods higher in craving compared to foods lower in craving. Most importantly, we did not observe any significant effects of oxytocin compared to placebo in motivational behaviour towards food. Our study demonstrates a general response bias towards foods with different craving values, which could have implications for future studies investigating food-related behaviour. We discuss possible explanations for the null effects of oxytocin and suggest further investigation of the relationship between oxytocin, dopamine and food-reward processing.",
keywords = "Adolescent, Adult, Algorithms, Avoidance Learning, Craving/drug effects, Cross-Over Studies, Cues, Double-Blind Method, Feeding Behavior/drug effects, Humans, Individuality, Male, Motivation/drug effects, Oxytocin/pharmacology, Reaction Time/drug effects, Young Adult, Health sciences, Psychology",
author = "Anna Melkonyan and Lu Liu and Brown, {Elliot C} and Willi Meyer and Madipakkam, {Apoorva Rajiv} and Lina Kalon and Franziska Lange and Schmid, {Sebastian M} and M{\"u}nte, {Thomas F} and Park, {Soyoung Q}",
note = "Publisher Copyright: {\textcopyright} 2020 The Authors. Journal of Neuroendocrinology published by John Wiley & Sons Ltd on behalf of British Society for Neuroendocrinology",
year = "2020",
month = dec,
day = "1",
doi = "10.1111/jne.12923",
language = "English",
volume = "32",
journal = "Journal of Neuroendocrinology",
issn = "0953-8194",
publisher = "Wiley-Blackwell Publishing Ltd.",
number = "12",

}

RIS

TY - JOUR

T1 - Unchanged food approach-avoidance behaviour of healthy men after oxytocin administration

AU - Melkonyan, Anna

AU - Liu, Lu

AU - Brown, Elliot C

AU - Meyer, Willi

AU - Madipakkam, Apoorva Rajiv

AU - Kalon, Lina

AU - Lange, Franziska

AU - Schmid, Sebastian M

AU - Münte, Thomas F

AU - Park, Soyoung Q

N1 - Publisher Copyright: © 2020 The Authors. Journal of Neuroendocrinology published by John Wiley & Sons Ltd on behalf of British Society for Neuroendocrinology

PY - 2020/12/1

Y1 - 2020/12/1

N2 - The oxytocinergic system has been assumed to contribute to food intake, possibly via interactions with dopamine. However, so far, it is unknown whether oxytocin influences the underlying motivational behaviour towards food. In the present study, we used a food-based approach-avoidance task (AAT) in a randomised, placebo-controlled, double-blind, cross-over design to compare intranasal oxytocin with a placebo. In the AAT, participants pushed or pulled a joystick when images of foods with a high or low craving rating were presented, where differences in response times typically reflect approach and avoidance motivational biases towards positively and negatively valence stimuli, respectively. Thirty-three healthy male participants (age = 25.12 ± 3.51 years; body mass index = 24.25 ± 2.48 kg/m2 ) completed the two-session study, one with placebo and the other with oxytocin. We used mixed-effects models to investigate effects of treatment (oxytocin, placebo), response type (approach, avoid) and stimulus (high, low craving). The results showed that both approach and avoid responses tended to be faster for foods higher in craving compared to foods lower in craving. Most importantly, we did not observe any significant effects of oxytocin compared to placebo in motivational behaviour towards food. Our study demonstrates a general response bias towards foods with different craving values, which could have implications for future studies investigating food-related behaviour. We discuss possible explanations for the null effects of oxytocin and suggest further investigation of the relationship between oxytocin, dopamine and food-reward processing.

AB - The oxytocinergic system has been assumed to contribute to food intake, possibly via interactions with dopamine. However, so far, it is unknown whether oxytocin influences the underlying motivational behaviour towards food. In the present study, we used a food-based approach-avoidance task (AAT) in a randomised, placebo-controlled, double-blind, cross-over design to compare intranasal oxytocin with a placebo. In the AAT, participants pushed or pulled a joystick when images of foods with a high or low craving rating were presented, where differences in response times typically reflect approach and avoidance motivational biases towards positively and negatively valence stimuli, respectively. Thirty-three healthy male participants (age = 25.12 ± 3.51 years; body mass index = 24.25 ± 2.48 kg/m2 ) completed the two-session study, one with placebo and the other with oxytocin. We used mixed-effects models to investigate effects of treatment (oxytocin, placebo), response type (approach, avoid) and stimulus (high, low craving). The results showed that both approach and avoid responses tended to be faster for foods higher in craving compared to foods lower in craving. Most importantly, we did not observe any significant effects of oxytocin compared to placebo in motivational behaviour towards food. Our study demonstrates a general response bias towards foods with different craving values, which could have implications for future studies investigating food-related behaviour. We discuss possible explanations for the null effects of oxytocin and suggest further investigation of the relationship between oxytocin, dopamine and food-reward processing.

KW - Adolescent

KW - Adult

KW - Algorithms

KW - Avoidance Learning

KW - Craving/drug effects

KW - Cross-Over Studies

KW - Cues

KW - Double-Blind Method

KW - Feeding Behavior/drug effects

KW - Humans

KW - Individuality

KW - Male

KW - Motivation/drug effects

KW - Oxytocin/pharmacology

KW - Reaction Time/drug effects

KW - Young Adult

KW - Health sciences

KW - Psychology

UR - http://www.scopus.com/inward/record.url?scp=85097497018&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/a095312d-a420-3a4c-9287-c2e6cbabf6f1/

U2 - 10.1111/jne.12923

DO - 10.1111/jne.12923

M3 - Journal articles

C2 - 33314397

VL - 32

JO - Journal of Neuroendocrinology

JF - Journal of Neuroendocrinology

SN - 0953-8194

IS - 12

M1 - e12923

ER -

Other publications by the same author(s)

Effectiveness of a guided multicomponent internet and mobile gratitude training program - A pragmatic randomized controlled trial

Lehr, D., Freund, H., Sieland, B., Kalon, L., Berking, M., Riper, H. & Ebert, D. D., 01.12.2024, In: Internet Interventions. 38, 12 p., 100787.

Research output: Journal contributions › Journal articles › Research › peer-review

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