While studies on self-reinforcing mechanisms in information systems (IS) research rely on methodologies that focus on the technical level without fully accounting for such effects on the organizational level, management research relies on methodologies that concentrate researchers’ efforts on the organizational level. The purpose of this paper is to introduce the Path Biography Methodology, a qualitative approach that helps researchers capture and analyze self-reinforcing mechanisms on and between technical and organizational levels. By synthesizing insights from IS and management research, we develop four principles that researchers should consider when applying the Path Biography Methodology. Using a path biography study of a university and its information system, we illustrate how researchers may apply this methodology to analyze self-reinforcing mechanisms. Overall, this paper lays the groundwork for a research methodology that enables researchers to capture and analyze self-reinforcing mechanisms on and between technical and organizational levels.