Reprint of: Improved cytotoxicity testing of magnesium materials
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Reprint of : Improved cytotoxicity testing of magnesium materials. / Fischer, Janine; Pröfrock, Daniel; Hort, Norbert et al.
In: Materials Science and Engineering: B, Vol. 176, No. 20, 15.12.2011, p. 1773-1777.Research output: Journal contributions › Journal articles › Research › peer-review
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TY - JOUR
T1 - Reprint of
T2 - Improved cytotoxicity testing of magnesium materials
AU - Fischer, Janine
AU - Pröfrock, Daniel
AU - Hort, Norbert
AU - Willumeit, Regine
AU - Feyerabend, Frank
PY - 2011/12/15
Y1 - 2011/12/15
N2 - Metallic magnesium (Mg) and its alloys are highly suitable for medical applications as biocompatible and biodegradable implant materials. Magnesium has mechanical properties similar to bone, stimulates bone regeneration, is an essential non-toxic element for the human body and degrades completely within the body environment. In consequence, magnesium is a promising candidate as implant material for orthopaedic applications. Protocols using the guideline of current ISO standards should be carefully evaluated when applying them for the characterization of the cytotoxic potential of degradable magnesium materials. For as-cast material we recommend using 10 times more extraction medium than recommended by the ISO standards to obtain reasonable results for reliable cytotoxicity rankings of degradable materials in vitro. In addition primary isolated human osteoblasts or mesenchymal stem cells should be used to test magnesium materials.
AB - Metallic magnesium (Mg) and its alloys are highly suitable for medical applications as biocompatible and biodegradable implant materials. Magnesium has mechanical properties similar to bone, stimulates bone regeneration, is an essential non-toxic element for the human body and degrades completely within the body environment. In consequence, magnesium is a promising candidate as implant material for orthopaedic applications. Protocols using the guideline of current ISO standards should be carefully evaluated when applying them for the characterization of the cytotoxic potential of degradable magnesium materials. For as-cast material we recommend using 10 times more extraction medium than recommended by the ISO standards to obtain reasonable results for reliable cytotoxicity rankings of degradable materials in vitro. In addition primary isolated human osteoblasts or mesenchymal stem cells should be used to test magnesium materials.
KW - Cytotoxicity tests
KW - Implants
KW - In vitro
KW - ISO standards
KW - Magnesium
KW - Osmolality
KW - Engineering
UR - http://www.scopus.com/inward/record.url?scp=80255132745&partnerID=8YFLogxK
U2 - 10.1016/j.mseb.2011.06.002
DO - 10.1016/j.mseb.2011.06.002
M3 - Journal articles
AN - SCOPUS:80255132745
VL - 176
SP - 1773
EP - 1777
JO - Materials Science and Engineering: B
JF - Materials Science and Engineering: B
SN - 0921-5107
IS - 20
ER -