Diverse learning groups in schools are a reality. In inclusive classrooms, teachers have to deal with diverse demands and therefore must adjust their teaching to the individual needs of every learner. Even though many teachers agree that the implementation of inclusive education is necessary as well as beneficial, at the same time many teachers in school practice do not feel ready or adequately prepared to deal with heterogeneous learning groups. Thus, there is a demand for concrete practices that help to realise inclusive teaching and learning that allows everyone to succeed. This contribution provides concrete practice-oriented suggestions of differentiated teaching practices that can be implemented by teachers in order to teach inclusively. In this article, the concept of differentiated instruction is clearly defined. A comprehensive overview of possible differentiation variants is also presented, and the practical suggestions are discussed in light of the increasing impact of digitisation.