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Activities of prenylphenol derivatives from fruitbodies of Albatrellus spp. on the human and rat vanilloid receptor 1 (VR 1) and characterisation of the novel natural product, confluentin

Research output: Journal contributions › Journal articles › Research

Standard

Activities of prenylphenol derivatives from fruitbodies of Albatrellus spp. on the human and rat vanilloid receptor 1 (VR 1) and characterisation of the novel natural product, confluentin. / Hellwig, Veronika; Nopper, Reilinde; Mauler, Frank et al.
In: Archiv der Pharmazie, Vol. 336, No. 2, 01.04.2003, p. 119-126.

Research output: Journal contributions › Journal articles › Research

Harvard

Hellwig, V, Nopper, R, Mauler, F, Freitag, J, Ji-Kai, L, Zhi-Hui, D & Stadler, M 2003, 'Activities of prenylphenol derivatives from fruitbodies of Albatrellus spp. on the human and rat vanilloid receptor 1 (VR 1) and characterisation of the novel natural product, confluentin', Archiv der Pharmazie, vol. 336, no. 2, pp. 119-126. https://doi.org/10.1002/ardp.200390008

APA

Hellwig, V., Nopper, R., Mauler, F., Freitag, J., Ji-Kai, L., Zhi-Hui, D., & Stadler, M. (2003). Activities of prenylphenol derivatives from fruitbodies of Albatrellus spp. on the human and rat vanilloid receptor 1 (VR 1) and characterisation of the novel natural product, confluentin. Archiv der Pharmazie, 336(2), 119-126. https://doi.org/10.1002/ardp.200390008

Vancouver

Hellwig V, Nopper R, Mauler F, Freitag J, Ji-Kai L, Zhi-Hui D et al. Activities of prenylphenol derivatives from fruitbodies of Albatrellus spp. on the human and rat vanilloid receptor 1 (VR 1) and characterisation of the novel natural product, confluentin. Archiv der Pharmazie. 2003 Apr 1;336(2):119-126. doi: 10.1002/ardp.200390008

Bibtex

@article{08944ec14c92456eb94e82739a64948f,
title = "Activities of prenylphenol derivatives from fruitbodies of Albatrellus spp. on the human and rat vanilloid receptor 1 (VR 1) and characterisation of the novel natural product, confluentin",
abstract = "Several prenylphenols from basidiocarps of European and Chinese Albatrellus spp., namely grifolin (1), neogrifolin (2), confluentin (3), scutigeral (4), and albaconol (5) were investigated concerning their activities in test models for vanilloid receptor modulation. The isolation of these compounds from A. confluens and structure elucidation of the novel natural product confluentin (3) are described. The effects of scutigeral and neogrifolin on vanilloid receptors were studied by means of electrophysiological methodology on rat dorsal root ganglion neurons as well as on recombinant cell lines expressing the rat VR1 receptor. Concurrently, the effects of compounds 1-5 on a reporter cell line expressing the human vanilloid receptor VR1 were measured. In contrast to previous studies reported in the literature, the results of these investigations suggest that fungal prenylphenols act as weak antagonists (activity in the μM range), rather than exhibiting agonistic activities.",
keywords = "Chemistry, Albaconol, Basidiomycetes, Grifolin, Neogrifolin, Pain, Scutigeral",
author = "Veronika Hellwig and Reilinde Nopper and Frank Mauler and Joachim Freitag and Liu Ji-Kai and Ding Zhi-Hui and Marc Stadler",
year = "2003",
month = apr,
day = "1",
doi = "10.1002/ardp.200390008",
language = "English",
volume = "336",
pages = "119--126",
journal = "Archiv der Pharmazie",
issn = "0365-6233",
publisher = "Wiley - VCH Verlag GmbH & CO. KGaA",
number = "2",

}

RIS

TY - JOUR

T1 - Activities of prenylphenol derivatives from fruitbodies of Albatrellus spp. on the human and rat vanilloid receptor 1 (VR 1) and characterisation of the novel natural product, confluentin

AU - Hellwig, Veronika

AU - Nopper, Reilinde

AU - Mauler, Frank

AU - Freitag, Joachim

AU - Ji-Kai, Liu

AU - Zhi-Hui, Ding

AU - Stadler, Marc

PY - 2003/4/1

Y1 - 2003/4/1

N2 - Several prenylphenols from basidiocarps of European and Chinese Albatrellus spp., namely grifolin (1), neogrifolin (2), confluentin (3), scutigeral (4), and albaconol (5) were investigated concerning their activities in test models for vanilloid receptor modulation. The isolation of these compounds from A. confluens and structure elucidation of the novel natural product confluentin (3) are described. The effects of scutigeral and neogrifolin on vanilloid receptors were studied by means of electrophysiological methodology on rat dorsal root ganglion neurons as well as on recombinant cell lines expressing the rat VR1 receptor. Concurrently, the effects of compounds 1-5 on a reporter cell line expressing the human vanilloid receptor VR1 were measured. In contrast to previous studies reported in the literature, the results of these investigations suggest that fungal prenylphenols act as weak antagonists (activity in the μM range), rather than exhibiting agonistic activities.

AB - Several prenylphenols from basidiocarps of European and Chinese Albatrellus spp., namely grifolin (1), neogrifolin (2), confluentin (3), scutigeral (4), and albaconol (5) were investigated concerning their activities in test models for vanilloid receptor modulation. The isolation of these compounds from A. confluens and structure elucidation of the novel natural product confluentin (3) are described. The effects of scutigeral and neogrifolin on vanilloid receptors were studied by means of electrophysiological methodology on rat dorsal root ganglion neurons as well as on recombinant cell lines expressing the rat VR1 receptor. Concurrently, the effects of compounds 1-5 on a reporter cell line expressing the human vanilloid receptor VR1 were measured. In contrast to previous studies reported in the literature, the results of these investigations suggest that fungal prenylphenols act as weak antagonists (activity in the μM range), rather than exhibiting agonistic activities.

KW - Chemistry

KW - Albaconol

KW - Basidiomycetes

KW - Grifolin

KW - Neogrifolin

KW - Pain

KW - Scutigeral

UR - http://www.scopus.com/inward/record.url?scp=0038373585&partnerID=8YFLogxK

U2 - 10.1002/ardp.200390008

DO - 10.1002/ardp.200390008

M3 - Journal articles

VL - 336

SP - 119

EP - 126

JO - Archiv der Pharmazie

JF - Archiv der Pharmazie

SN - 0365-6233

IS - 2

ER -

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Research output: Journal contributions › Journal articles › Research › peer-review

DOI