Accelerated dereplication of natural products, supported by reference libraries

Research output: Journal contributionsJournal articlesResearch

Authors

  • Jens Bitzer
  • Bärbel Köpcke
  • Marc Stadler
  • Veronika Hellwig
  • Yu-Ming Ju
  • Stephan Seip
  • Thomas Henkel

Natural products are an indispensable source for drug discovery. The major challenge for exploiting this evolutionary optimized pool of potential lead structures is the fast and reliable recognition of known compounds, i.e. dereplication. This task is essential for the discovery process in high-throughput screening scenarios, since it allows the focus to be placed on novel chemical structures at an early stage. Furthermore, information on identified compounds will help to rationalize observed bioactivities. This article describes an effective, library-supported strategy for the dereplication of crude extracts and pre-fractionated samples, using an HPLC-based multidetector platform and NMR techniques, respectively.

Original languageEnglish
JournalChimia
Volume61
Issue number6
Pages (from-to)332-338
Number of pages7
ISSN0009-4293
DOIs
Publication statusPublished - 27.06.2007

    Research areas

  • Chemistry - dereplication, multirdetector hplc, natural products, nmr, secondary metabolites, tandem mass spectrometry

DOI

Recently viewed

Researchers

  1. Felix Lemke

Activities

  1. 3rd IMPRES Symposium 2013
  2. Ringvorlesung "Maple Leaf & Stars and Stripes" WiSe 2017/2018
  3. Postervortrag: Science Education Research and Practical Work, mit Elisabeth Hofer und Anja Lembens
  4. Developing pragmatic competence in a study abroad context (International Pragmatics Conference - IPrA 2017: Pragmatics in the real world, Belfast)
  5. 6th Conference on Recent Advances in Space Technologies - RAST 2013
  6. The organizational representativity of NGOs in EU policy-making
  7. Language Related Research (Fachzeitschrift)
  8. Arts and culture as urban development tool: a comparative study in Baltimore and Hamburg
  9. Leuphana Universität Lüneburg (Organisation)
  10. Classical music making in artistic precarity
  11. MindTrek 2017 (Veranstaltung)
  12. Seed fate of common grassland species along an experimental plant diversity gradient
  13. BMBF-Foresight-Workshop »Forschungsperspek­tive Mensch-Technik-Grenzverschiebungen«
  14. Studienerfolg mittels Learning Analytics – Systematisches Review
  15. Conference „Managing the way out of the crisis: between regulation and forecasts“ 2011
  16. Conference Image Politics – Pictur(e)ing Climate – Visualizations, Imaginations, Documentations 2012
  17. Kongress der Deutschen Gesellschaft für Fremdsprachenforschung 2017
  18. Lernaufgaben im Kontext einer BBNE
  19. Leuphana Universität Lüneburg (Organisation)
  20. 11th Biennial Conference on Environmental Psychology - BCEP 2015
  21. Vortrag: Organisation unternehmerischer Nachhaltigkeit
  22. International Association for Conflict Management (Externe Organisation)
  23. Wahrheit und Wahrhaftigkeit