Altersetin, a new antibiotic from cultures of endophytic Alternaria spp. taxonomy, fermentation, isolation, structure elucidation and biological activities: taxonomy, fermentation, isolation, structure elucidation and biological activites

Research output: Journal contributionsJournal articlesResearch

Authors

  • Veronika Hellwig
  • Torsten Grothe
  • Anke Mayer-Bartschmid
  • Rainer Endermann
  • Frank-Ulrich Geschke
  • Thomas Henkel
  • Marc Stadler

A novel antibacterial antibiotic, for which the name altersetin is proposed, was isolated from the culture broth of two endophytic Alternaria species. The relative and absolute configuration were assigned by NOESY or CD data, respectively. Altersetin is chemically related to equisetin and showed potent MIC against several pathogenic Gram-positive bacteria, whereas Gram-negative bacteria and pathogenic yeast were not or much less susceptible. Moderate in vivo efficiacy was observed for altersetin in a murine sepsis model.

Original languageEnglish
JournalJournal of Antibiotics
Volume55
Issue number10
Pages (from-to)881-892
Number of pages12
ISSN0021-8820
DOIs
Publication statusPublished - 01.10.2002
Externally publishedYes