Altersetin, a new antibiotic from cultures of endophytic Alternaria spp. taxonomy, fermentation, isolation, structure elucidation and biological activities: taxonomy, fermentation, isolation, structure elucidation and biological activites
Research output: Journal contributions › Journal articles › Research
Authors
A novel antibacterial antibiotic, for which the name altersetin is proposed, was isolated from the culture broth of two endophytic Alternaria species. The relative and absolute configuration were assigned by NOESY or CD data, respectively. Altersetin is chemically related to equisetin and showed potent MIC against several pathogenic Gram-positive bacteria, whereas Gram-negative bacteria and pathogenic yeast were not or much less susceptible. Moderate in vivo efficiacy was observed for altersetin in a murine sepsis model.
| Original language | English |
|---|---|
| Journal | Journal of Antibiotics |
| Volume | 55 |
| Issue number | 10 |
| Pages (from-to) | 881-892 |
| Number of pages | 12 |
| ISSN | 0021-8820 |
| DOIs | |
| Publication status | Published - 01.10.2002 |
| Externally published | Yes |
- Chemistry
Research areas
- Drug Discovery
- Pharmacology