TY - JOUR

T1 - Treatment of comorbid alcohol use disorders and depression with cognitive-behavioural therapy and motivational interviewing

T2 - A meta-analysis

AU - Riper, Heleen

AU - Andersson, Gerhard

AU - Hunter, Sarah B.

AU - de Wit, Jessica

AU - Berking, Matthias

AU - Cuijpers, Pim

PY - 2014/3

Y1 - 2014/3

N2 - Background and Aims: To review published studies on the effectiveness of combining cognitive-behavioural therapy (CBT) and motivational interviewing (MI) to treat comorbid clinical and subclinical alcohol use disorder (AUD) and major depression (MDD) and estimate the effect of this compared with usual care. Methods: We conducted systematic literature searches in PubMed, PsycINFO and Embase up to June 2013 and identified additional studies through cross-references in included studies and systematic reviews. Twelve studies comprising 1721 patients met our inclusion criteria. The studies had sufficient statistical power to detect small effect sizes. Results: CBT/MI proved effective for treating subclinical and clinical AUD and MDD compared with controls, with small overall effect sizes at post-treatment [g=0.17, confidence interval (CI)=0.07-0.28, P<0.001 for decrease of alcohol consumption and g=0.27, CI: 0.13-0.41, P<0.001 for decrease of symptoms of depression, respectively]. Subgroup analyses revealed no significant differences for both AUD and MDD. However, digital interventions showed a higher effect size for depression than face-to-face interventions (g=0.73 and g=0.23, respectively, P=0.030). Conclusions: Combined cognitive-behavioural therapy and motivational interviewing for clinical or subclinical depressive and alcohol use disorders has a small but clinically significant effect in treatment outcomes compared with treatment as usual.

AB - Background and Aims: To review published studies on the effectiveness of combining cognitive-behavioural therapy (CBT) and motivational interviewing (MI) to treat comorbid clinical and subclinical alcohol use disorder (AUD) and major depression (MDD) and estimate the effect of this compared with usual care. Methods: We conducted systematic literature searches in PubMed, PsycINFO and Embase up to June 2013 and identified additional studies through cross-references in included studies and systematic reviews. Twelve studies comprising 1721 patients met our inclusion criteria. The studies had sufficient statistical power to detect small effect sizes. Results: CBT/MI proved effective for treating subclinical and clinical AUD and MDD compared with controls, with small overall effect sizes at post-treatment [g=0.17, confidence interval (CI)=0.07-0.28, P<0.001 for decrease of alcohol consumption and g=0.27, CI: 0.13-0.41, P<0.001 for decrease of symptoms of depression, respectively]. Subgroup analyses revealed no significant differences for both AUD and MDD. However, digital interventions showed a higher effect size for depression than face-to-face interventions (g=0.73 and g=0.23, respectively, P=0.030). Conclusions: Combined cognitive-behavioural therapy and motivational interviewing for clinical or subclinical depressive and alcohol use disorders has a small but clinically significant effect in treatment outcomes compared with treatment as usual.

KW - Health sciences

KW - Alcohol use disorders

KW - Cognitive-behavioural therapy

KW - Comorbidity

KW - Major depression

KW - Meta-analysis

KW - Motivational interviewing

KW - Randomized controlled trials

KW - Treatment effect

UR - http://www.scopus.com/inward/record.url?scp=84893872400&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/9877aebf-5e9c-32be-8dad-dcee9c942eaf/

U2 - 10.1111/add.12441

DO - 10.1111/add.12441

M3 - Scientific review articles

C2 - 24304463

AN - SCOPUS:84893872400

VL - 109

SP - 394

EP - 406

JO - Addiction: The British journal of addiction to alcohol and other drugs

JF - Addiction: The British journal of addiction to alcohol and other drugs

SN - 0965-2140

IS - 3

ER -