Recalcitrant pharmaceuticals in the aquatic environment: A comparative screening study of their occurrence, formation of phototransformation products and their in vitro toxicity

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Recalcitrant pharmaceuticals in the aquatic environment : A comparative screening study of their occurrence, formation of phototransformation products and their in vitro toxicity. / Bergheim, Marlies; Gminski, Richard; Spangenberg, Bernd et al.

in: Environmental Chemistry, Jahrgang 11, Nr. 4, 2014, S. 431-444.

Publikation: Beiträge in ZeitschriftenZeitschriftenaufsätzeForschungbegutachtet

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@article{a197f21c386942548bf5a9f4816d405c,
title = "Recalcitrant pharmaceuticals in the aquatic environment: A comparative screening study of their occurrence, formation of phototransformation products and their in vitro toxicity",
abstract = "Data allowing for a complete environmental risk assessment of pharmaceuticals and their photoderatives in the environment are still scarce. In the present study, in vitro toxicity and both bio- and photopersistence of various pharmaceuticals (aciclovir, allopurinol, cetirizine, cimetidine, fluconazole, hydrochlorothiazide, lisinopril, phenytoin, primidone, ranitidine, sotalol, sulpiride, tramadol and valsartane) as well as their phototransformation products were evaluated in order to fill data gaps and to help prioritise them for further testing. Twelve out of the fourteen compounds investigated were found to be neither readily nor inherently biodegradable in the Organisation of Economic Cooperation and Development-biodegradability tests. The study further demonstrates that the photo-induced transformation of the pharmaceuticals was faster upon irradiation with a Hg lamp (UV light) than with a Xe lamp emitting a spectrum that mimics sunlight. Comparing the non-irradiated with the respective irradiated solutions, a higher acute and chronic toxicity against bacteria was found for the irradiated solutions of seven compounds (cetirizine, cimetidine, hydrochlorothiazide, ranitidine, sulpiride, tramadol and valsartane). No cyto- and genotoxic effects were found in human cervical (HeLa) and liver (Hep-G2) cells for any of the investigated compounds or their phototransformation products. This comparative study documents that phototransformation products can arise as a result of UV treatment of wastewater containing these pharmaceuticals. It further demonstrates that some phototransformation products may have a higher environmental risk potential than the respective parent compounds because some phototransformation products exhibited a higher bacterial toxicity.",
keywords = "Sustainability Science, Biodegradation, HeLa cells, Hep-G2 cells, Irradiation, Predicted environmental concentrations (PECs), UV, Vibrio fischeri, Biodegradation, HeLa cells, Hep-G2 cells, Irradiation, Predicted environmental concentrations (PECs), Vibrio fischeri, UV",
author = "Marlies Bergheim and Richard Gminski and Bernd Spangenberg and Malgorzata Dȩbiak and Alexander B{\"u}rkle and Volker Mersch-Sundermann and Klaus K{\"u}mmerer and Reto Gier{\'e}",
year = "2014",
doi = "10.1071/EN13218",
language = "English",
volume = "11",
pages = "431--444",
journal = "Environmental Chemistry",
issn = "1448-2517",
publisher = "CSIRO",
number = "4",

}

RIS

TY - JOUR

T1 - Recalcitrant pharmaceuticals in the aquatic environment

T2 - A comparative screening study of their occurrence, formation of phototransformation products and their in vitro toxicity

AU - Bergheim, Marlies

AU - Gminski, Richard

AU - Spangenberg, Bernd

AU - Dȩbiak, Malgorzata

AU - Bürkle, Alexander

AU - Mersch-Sundermann, Volker

AU - Kümmerer, Klaus

AU - Gieré, Reto

PY - 2014

Y1 - 2014

N2 - Data allowing for a complete environmental risk assessment of pharmaceuticals and their photoderatives in the environment are still scarce. In the present study, in vitro toxicity and both bio- and photopersistence of various pharmaceuticals (aciclovir, allopurinol, cetirizine, cimetidine, fluconazole, hydrochlorothiazide, lisinopril, phenytoin, primidone, ranitidine, sotalol, sulpiride, tramadol and valsartane) as well as their phototransformation products were evaluated in order to fill data gaps and to help prioritise them for further testing. Twelve out of the fourteen compounds investigated were found to be neither readily nor inherently biodegradable in the Organisation of Economic Cooperation and Development-biodegradability tests. The study further demonstrates that the photo-induced transformation of the pharmaceuticals was faster upon irradiation with a Hg lamp (UV light) than with a Xe lamp emitting a spectrum that mimics sunlight. Comparing the non-irradiated with the respective irradiated solutions, a higher acute and chronic toxicity against bacteria was found for the irradiated solutions of seven compounds (cetirizine, cimetidine, hydrochlorothiazide, ranitidine, sulpiride, tramadol and valsartane). No cyto- and genotoxic effects were found in human cervical (HeLa) and liver (Hep-G2) cells for any of the investigated compounds or their phototransformation products. This comparative study documents that phototransformation products can arise as a result of UV treatment of wastewater containing these pharmaceuticals. It further demonstrates that some phototransformation products may have a higher environmental risk potential than the respective parent compounds because some phototransformation products exhibited a higher bacterial toxicity.

AB - Data allowing for a complete environmental risk assessment of pharmaceuticals and their photoderatives in the environment are still scarce. In the present study, in vitro toxicity and both bio- and photopersistence of various pharmaceuticals (aciclovir, allopurinol, cetirizine, cimetidine, fluconazole, hydrochlorothiazide, lisinopril, phenytoin, primidone, ranitidine, sotalol, sulpiride, tramadol and valsartane) as well as their phototransformation products were evaluated in order to fill data gaps and to help prioritise them for further testing. Twelve out of the fourteen compounds investigated were found to be neither readily nor inherently biodegradable in the Organisation of Economic Cooperation and Development-biodegradability tests. The study further demonstrates that the photo-induced transformation of the pharmaceuticals was faster upon irradiation with a Hg lamp (UV light) than with a Xe lamp emitting a spectrum that mimics sunlight. Comparing the non-irradiated with the respective irradiated solutions, a higher acute and chronic toxicity against bacteria was found for the irradiated solutions of seven compounds (cetirizine, cimetidine, hydrochlorothiazide, ranitidine, sulpiride, tramadol and valsartane). No cyto- and genotoxic effects were found in human cervical (HeLa) and liver (Hep-G2) cells for any of the investigated compounds or their phototransformation products. This comparative study documents that phototransformation products can arise as a result of UV treatment of wastewater containing these pharmaceuticals. It further demonstrates that some phototransformation products may have a higher environmental risk potential than the respective parent compounds because some phototransformation products exhibited a higher bacterial toxicity.

KW - Sustainability Science

KW - Biodegradation

KW - HeLa cells

KW - Hep-G2 cells

KW - Irradiation

KW - Predicted environmental concentrations (PECs)

KW - UV

KW - Vibrio fischeri

KW - Biodegradation

KW - HeLa cells

KW - Hep-G2 cells

KW - Irradiation

KW - Predicted environmental concentrations (PECs)

KW - Vibrio fischeri

KW - UV

UR - http://www.scopus.com/inward/record.url?scp=84906669875&partnerID=8YFLogxK

U2 - 10.1071/EN13218

DO - 10.1071/EN13218

M3 - Journal articles

AN - SCOPUS:84906669875

VL - 11

SP - 431

EP - 444

JO - Environmental Chemistry

JF - Environmental Chemistry

SN - 1448-2517

IS - 4

ER -

DOI