TY - JOUR

T1 - Potential bias in meta-analyses of effect sizes in imaging genetics

AU - Paulus, Frieder M.

AU - Krach, Sören

AU - Albrecht, Anne Grit

AU - Jansen, Andreas

PY - 2013/5

Y1 - 2013/5

N2 - The penetrance of genetic variation has been assumed to be higher at the level of neural phenotypes than at the level of behavioral phenotypes. One of the few attempts to validate this assumption is the study of Rose and Donohoe published in this issue. In this article, we will address 2 methodological issues we believe have to be considered for a better understanding of the present results. We briefly discuss potential solutions that might also help improve future meta-analyses of effect sizes in neuroimaging data.

AB - The penetrance of genetic variation has been assumed to be higher at the level of neural phenotypes than at the level of behavioral phenotypes. One of the few attempts to validate this assumption is the study of Rose and Donohoe published in this issue. In this article, we will address 2 methodological issues we believe have to be considered for a better understanding of the present results. We briefly discuss potential solutions that might also help improve future meta-analyses of effect sizes in neuroimaging data.

KW - effect sizes

KW - imaging genetics

KW - meta-analysis

KW - schizophrenia

KW - Management studies

UR - http://www.scopus.com/inward/record.url?scp=84876580334&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/6bd830d6-6080-34ef-8021-7a864986e26f/

U2 - 10.1093/schbul/sbt035

DO - 10.1093/schbul/sbt035

M3 - Comments / Debate / Reports

C2 - 23474966

AN - SCOPUS:84876580334

VL - 39

SP - 501

EP - 503

JO - Schizophrenia Bulletin

JF - Schizophrenia Bulletin

SN - 0586-7614

IS - 3

ER -