Do guided internet-based interventions result in clinically relevant changes for patients with depression? An individual participant data meta-analysis

Publikation: Beiträge in ZeitschriftenÜbersichtsarbeitenForschung

Authors

  • Eirini Karyotaki
  • David Daniel Ebert
  • Liesje Donkin
  • Heleen Riper
  • Jos Twisk
  • Simone Burger
  • Alexander Rozental
  • Alfred Lange
  • Alishia D. Williams
  • Anna Carlotta Zarski
  • Anna Geraedts
  • Annemieke van Straten
  • Annet Kleiboer
  • Björn Meyer
  • Burçin B. Ünlü Ince
  • Claudia Buntrock
  • Frank J. Snoek
  • Gavin Andrews
  • Gerhard Andersson
  • Isabella Choi
  • Jeroen Ruwaard
  • Jan Philipp Klein
  • Jill M. Newby
  • Johanna Schröder
  • Johannes A.C. Laferton
  • Kim Van Bastelaar
  • Kotaro Imamura
  • Kristofer Vernmark
  • Lisa B. Sheeber
  • Marie Kivi
  • Matthias Berking
  • Nickolai Titov
  • Per Carlbring
  • Robert Johansson
  • Robin Kenter
  • Sarah Perini
  • Steffen Moritz
  • Stephanie Nobis
  • Thomas Berger
  • Viktor Kaldo
  • Yvonne Forsell
  • Nils Lindefors
  • Martin Kraepelien
  • Cecilia Björkelund
  • Norito Kawakami
  • Pim Cuijpers

Little is known about clinically relevant changes in guided Internet-based interventions for depression. Moreover, methodological and power limitations preclude the identification of patients’ groups that may benefit more from these interventions. This study aimed to investigate response rates, remission rates, and their moderators in randomized controlled trials (RCTs) comparing the effect of guided Internet-based interventions for adult depression to control groups using an individual patient data meta-analysis approach. Literature searches in PubMed, Embase, PsycINFO and Cochrane Library resulted in 13,384 abstracts from database inception to January 1, 2016. Twenty-four RCTs (4889 participants) comparing a guided Internet-based intervention with a control group contributed data to the analysis. Missing data were multiply imputed. To examine treatment outcome on response and remission, mixed-effects models with participants nested within studies were used. Response and remission rates were calculated using the Reliable Change Index. The intervention group obtained significantly higher response rates (OR = 2.49, 95% CI 2.17–2.85) and remission rates compared to controls (OR = 2.41, 95% CI 2.07–2.79). The moderator analysis indicated that older participants (OR = 1.01) and native-born participants (1.66) were more likely to respond to treatment compared to younger participants and ethnic minorities respectively. Age (OR = 1.01) and ethnicity (1.73) also moderated the effects of treatment on remission.Moreover, adults with more severe depressive symptoms at baseline were more likely to remit after receiving internet-based treatment (OR = 1.19). Guided Internet-based interventions lead to substantial positive treatment effects on treatment response and remission at post-treatment. Thus, such interventions may complement existing services for depression and potentially reduce the gap between the need and provision of evidence-based treatments.

OriginalspracheEnglisch
ZeitschriftClinical Psychology Review
Jahrgang63
Seiten (von - bis)80-92
Anzahl der Seiten13
ISSN0272-7358
DOIs
PublikationsstatusErschienen - 01.07.2018

DOI

Zuletzt angesehen

Publikationen

  1. Critical reflections on ethnographic data collection in the highly gendered environment of male football.
  2. An automated, modular system for organic waste utilization using heterotrophic alga Galdieria sulphuraria
  3. "Nachhaltigkeit, wat juckt mich das?" - Betriebliches nachhaltiges Handeln aus Perspektive der Auszubildenden
  4. Führt Bürgerbeteiligung in umweltpolitischen Entscheidungsprozessen zu mehr Effektivität und Legitimität?
  5. Entschleunigung von innerörtlichem Durchgangsverkehr durch künstlerische Installationen im Straßenraum
  6. Microstructure and Microhardness of Wire-based Laser Metal Deposited AA5087 using an Ytterbium Fibre Laser
  7. Heterotrophic growth of Galdieria sulphuraria on residues from aquaculture and fish processing industries
  8. Toward Application and Implementation of in Silico Tools and Workflows within Benign by Design Approaches
  9. A latent state-trait analysis of current achievement motivation across different tasks of cognitive ability
  10. Effect of filler wire and post weld heat treatment on the mechanical properties of laser beam-welded AA2198
  11. The role of self-evaluation in predicting attitudes toward supporters of COVID-19-related conspiracy theories
  12. Franchising as a Strategy for Combining Small and Large Group Advantages (Logics) in Social Entrepreneurship
  13. Incremental analysis of springback and kinematic hardening by the variation of tension during deep drawing
  14. Modeling of lateness distributions depending on the sequencing method with respect to productivity effects
  15. Matanzas, Cuba, ca.1957: Afro-Cuban sacred music from the countryside - Smithsonian Folkways Recordings SFW 40490
  16. Applying Quarter-Vehicle Model Simulation for Road Elevation Measurements Utilizing the Vehicle Level Sensor
  17. Kulturelle Hybridität und Transfer. Black Britain in der (ins Deutsche übersetzten) Kinder- und Jugendliteratur
  18. Die Praxis der Innovationsforschung – im Spannungsfeld von Wissenschaft, Ökonomie, Steuerung und Organisation
  19. Investigating the Dual Role of Price on Consumers’ Purchase Intentions of Hedonic versus Utilitarian Products:
  20. The Effects of general and specific human capital on long-term growth and failure of newly founded businesses
  21. August Sauer, die Gründung des "Euphorion" und die Modernisierung der Germanistik im Ausgang des 19. Jahrhunderts