Transformation products of sulfonamides in aquatic systems: Lessons learned from available environmental fate and behaviour data
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In: Science of the Total Environment, Vol. 830, 154744, 15.07.2022.
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TY - JOUR
T1 - Transformation products of sulfonamides in aquatic systems
T2 - Lessons learned from available environmental fate and behaviour data
AU - Puhlmann, Neele
AU - Olsson, Oliver
AU - Kümmerer, Klaus
N1 - Copyright © 2022 Elsevier B.V. All rights reserved.
PY - 2022/7/15
Y1 - 2022/7/15
N2 - Sulfonamides (SUAs) and their transformation products (TPs) contribute to environmental pollution. Importance of research on TPs' properties has been emphasised, e.g. allowing a comprehensive environmental risk assessment of their parent compounds. However, TPs' properties have been discussed in reviews on SUAs only marginally, if at all. For the first time, a scientific literature review aims to discuss the current state of knowledge on SUA-TPs including research gaps, and commonalities of SUA-TPs and TPs in general. Literature on SUA-TPs was consulted systematically to collect data on occurrence, physicochemical properties, degradability, and (eco)toxicity. TPs of 14 SUAs were reviewed, and aspects applicable for TPs in general were identified to guide future handling of TPs as a complex category of compounds. The data of sulfamethoxazole (SMX), the main representative, was analysed in more detail to discuss insights on a chemical level. Literature search resulted in 607 SUA-TPs reported in 222 publications. Only for 4%, 31%, and 35% of these TPs, data on occurrence in aquatic systems, on degradation, and (eco)toxicity, respectively, was found. Several mixtures of SUA-TPs were more ecotoxic than their parent compounds, e.g. 10 of 15 mixtures of SMX-TPs. Only few TPs were tested as single substance. Although several TPs could be eliminated experimentally, their mineralisation rate remained often unknown. Thus, further transformation to persistent TPs could not be ruled out. Standardised biodegradability tests of individual TPs would monitor their mineralisation rate, but are almost completely lacking. Reasons are likely poor availability of TPs, but also the focus on abiotic water treatment. Data assessment demonstrated that data of high significance according to standard methods, e.g. OECD methods for chronic (eco)toxicity and ready biodegradability, is needed to assess environmental risks of prioritised TPs, but also to redesign their parent pharmaceutical for complete environmental mineralisation in a long-term (Benign by Design).
AB - Sulfonamides (SUAs) and their transformation products (TPs) contribute to environmental pollution. Importance of research on TPs' properties has been emphasised, e.g. allowing a comprehensive environmental risk assessment of their parent compounds. However, TPs' properties have been discussed in reviews on SUAs only marginally, if at all. For the first time, a scientific literature review aims to discuss the current state of knowledge on SUA-TPs including research gaps, and commonalities of SUA-TPs and TPs in general. Literature on SUA-TPs was consulted systematically to collect data on occurrence, physicochemical properties, degradability, and (eco)toxicity. TPs of 14 SUAs were reviewed, and aspects applicable for TPs in general were identified to guide future handling of TPs as a complex category of compounds. The data of sulfamethoxazole (SMX), the main representative, was analysed in more detail to discuss insights on a chemical level. Literature search resulted in 607 SUA-TPs reported in 222 publications. Only for 4%, 31%, and 35% of these TPs, data on occurrence in aquatic systems, on degradation, and (eco)toxicity, respectively, was found. Several mixtures of SUA-TPs were more ecotoxic than their parent compounds, e.g. 10 of 15 mixtures of SMX-TPs. Only few TPs were tested as single substance. Although several TPs could be eliminated experimentally, their mineralisation rate remained often unknown. Thus, further transformation to persistent TPs could not be ruled out. Standardised biodegradability tests of individual TPs would monitor their mineralisation rate, but are almost completely lacking. Reasons are likely poor availability of TPs, but also the focus on abiotic water treatment. Data assessment demonstrated that data of high significance according to standard methods, e.g. OECD methods for chronic (eco)toxicity and ready biodegradability, is needed to assess environmental risks of prioritised TPs, but also to redesign their parent pharmaceutical for complete environmental mineralisation in a long-term (Benign by Design).
KW - Assessment
KW - Degradability
KW - Ecotoxicity
KW - Pharmaceutical
KW - Risk
KW - Treatment
KW - Chemistry
UR - http://www.scopus.com/inward/record.url?scp=85127361220&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/58106095-f678-36a2-aaed-d32adba61c4a/
U2 - 10.48548/pubdata-130
DO - 10.48548/pubdata-130
M3 - Scientific review articles
C2 - 35339561
AN - SCOPUS:85127361220
VL - 830
JO - Science of the Total Environment
JF - Science of the Total Environment
SN - 0048-9697
M1 - 154744
ER -