TY - JOUR

T1 - Trace Analysis of the Antineoplastics Ifosfamide and Cyclophosphamide in Sewage Water by Two-Step Solid-Phase Extraction and Gas Chromatography Mass Spectrometry

AU - Steger-Hartmann, Thomas

AU - Kümmerer, Klaus

AU - Schecker, Jörn

PY - 1996/3/1

Y1 - 1996/3/1

N2 - A sensitive, specific and highly reproducible method for the analysis of the two antineoplastics, ifosfamide and cyclophosphamide, in sewage water at the ppt-level is presented. The method includes a two-step solid-phase extraction (SPE) on C-18 and SiOH material and GC-MS analysis using single ion monitoring (SIM). The method was applied to degradational studies of the two drugs in laboratory-scale sewage treatment plants (LSSTPs) and to quantification in hospital sewage water samples. It was shown that the drugs were not degraded in LSSTPs and that they turned up in hospital sewage water

AB - A sensitive, specific and highly reproducible method for the analysis of the two antineoplastics, ifosfamide and cyclophosphamide, in sewage water at the ppt-level is presented. The method includes a two-step solid-phase extraction (SPE) on C-18 and SiOH material and GC-MS analysis using single ion monitoring (SIM). The method was applied to degradational studies of the two drugs in laboratory-scale sewage treatment plants (LSSTPs) and to quantification in hospital sewage water samples. It was shown that the drugs were not degraded in LSSTPs and that they turned up in hospital sewage water

KW - Chemistry

KW - Solid-phase extration

KW - Waster water

KW - Ifosfamide

KW - Cyclophosphamide

UR - http://www.scopus.com/inward/record.url?scp=0002837142&partnerID=8YFLogxK

U2 - 10.1016/0021-9673(95)01063-7

DO - 10.1016/0021-9673(95)01063-7

M3 - Journal articles

VL - 726

SP - 179

EP - 184

JO - Journal of Chromatography A

JF - Journal of Chromatography A

SN - 0021-9673

IS - 1-2

ER -