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Control condition design and implementation features in controlled trials: A meta-analysis of trials evaluating psychotherapy for depression

Research output: Journal contributions › Scientific review articles › Research

Standard

Control condition design and implementation features in controlled trials: A meta-analysis of trials evaluating psychotherapy for depression. / Mohr, David C.; Ho, Joyce; Hart, Tae L et al.
In: Translational Behavioral Medicine, Vol. 4, No. 4, 12.2014, p. 407-423.

Research output: Journal contributions › Scientific review articles › Research

Harvard

Mohr, DC, Ho, J, Hart, TL, Baron, K, Berendsen, M, Beckner, V, Cai, X, Cuijpers, P, Spring, B, W Kinsinger, S, Schroder, K & Duffecy, J 2014, 'Control condition design and implementation features in controlled trials: A meta-analysis of trials evaluating psychotherapy for depression', Translational Behavioral Medicine, vol. 4, no. 4, pp. 407-423. https://doi.org/10.1007/s13142-014-0262-3

APA

Mohr, D. C., Ho, J., Hart, T. L., Baron, K., Berendsen, M., Beckner, V., Cai, X., Cuijpers, P., Spring, B., W Kinsinger, S., Schroder, K., & Duffecy, J. (2014). Control condition design and implementation features in controlled trials: A meta-analysis of trials evaluating psychotherapy for depression. Translational Behavioral Medicine, 4(4), 407-423. https://doi.org/10.1007/s13142-014-0262-3

Vancouver

Mohr DC, Ho J, Hart TL, Baron K, Berendsen M, Beckner V et al. Control condition design and implementation features in controlled trials: A meta-analysis of trials evaluating psychotherapy for depression. Translational Behavioral Medicine. 2014 Dec;4(4):407-423. doi: 10.1007/s13142-014-0262-3

Bibtex

@article{090c2030bd3342c39d6adc5037e634ac,
title = "Control condition design and implementation features in controlled trials: A meta-analysis of trials evaluating psychotherapy for depression",
abstract = "Abstract: Control conditions are the primary methodology used to reduce threats to internal validity in randomized controlled trials (RCTs). This meta-analysis examined the effects of control arm design and implementation on outcomes in RCTs examining psychological treatments for depression. A search of MEDLINE, PsycINFO, and EMBASE identified all RCTs evaluating psychological treatments for depression published through June 2009. Data were analyzed using mixed-effects models. One hundred twenty-five trials were identified yielding 188 comparisons. Outcomes varied significantly depending control condition design (p < 0.0001). Significantly smaller effect sizes were seen when control arms used manualization (p = 0.006), therapist training (p = 0.002), therapist supervision (p = 0.009), and treatment fidelity monitoring (p = 0.003). There were no significant effects for differences in therapist experience, level of expertise in the treatment delivered, or nesting vs. crossing therapists in treatment arms. These findings demonstrate the substantial effect that decisions regarding control arm definition and implementation can have on RCT outcomes.",
keywords = "Psychology, Health sciences, Control conditions, Depression, Meta-analysis, Methodology, Randomized controlled trial design",
author = "Mohr, {David C.} and Joyce Ho and Hart, {Tae L} and Kelly Baron and Mark Berendsen and Victoria Beckner and Xuan Cai and Pim Cuijpers and Bonnie Spring and {W Kinsinger}, Sarah and Kerstin Schroder and Jenna Duffecy",
year = "2014",
month = dec,
doi = "10.1007/s13142-014-0262-3",
language = "English",
volume = "4",
pages = "407--423",
journal = "Translational Behavioral Medicine",
issn = "1869-6716",
publisher = "Oxford University Press",
number = "4",

}

RIS

TY - JOUR

T1 - Control condition design and implementation features in controlled trials

T2 - A meta-analysis of trials evaluating psychotherapy for depression

AU - Mohr, David C.

AU - Ho, Joyce

AU - Hart, Tae L

AU - Baron, Kelly

AU - Berendsen, Mark

AU - Beckner, Victoria

AU - Cai, Xuan

AU - Cuijpers, Pim

AU - Spring, Bonnie

AU - W Kinsinger, Sarah

AU - Schroder, Kerstin

AU - Duffecy, Jenna

PY - 2014/12

Y1 - 2014/12

N2 - Abstract: Control conditions are the primary methodology used to reduce threats to internal validity in randomized controlled trials (RCTs). This meta-analysis examined the effects of control arm design and implementation on outcomes in RCTs examining psychological treatments for depression. A search of MEDLINE, PsycINFO, and EMBASE identified all RCTs evaluating psychological treatments for depression published through June 2009. Data were analyzed using mixed-effects models. One hundred twenty-five trials were identified yielding 188 comparisons. Outcomes varied significantly depending control condition design (p < 0.0001). Significantly smaller effect sizes were seen when control arms used manualization (p = 0.006), therapist training (p = 0.002), therapist supervision (p = 0.009), and treatment fidelity monitoring (p = 0.003). There were no significant effects for differences in therapist experience, level of expertise in the treatment delivered, or nesting vs. crossing therapists in treatment arms. These findings demonstrate the substantial effect that decisions regarding control arm definition and implementation can have on RCT outcomes.

AB - Abstract: Control conditions are the primary methodology used to reduce threats to internal validity in randomized controlled trials (RCTs). This meta-analysis examined the effects of control arm design and implementation on outcomes in RCTs examining psychological treatments for depression. A search of MEDLINE, PsycINFO, and EMBASE identified all RCTs evaluating psychological treatments for depression published through June 2009. Data were analyzed using mixed-effects models. One hundred twenty-five trials were identified yielding 188 comparisons. Outcomes varied significantly depending control condition design (p < 0.0001). Significantly smaller effect sizes were seen when control arms used manualization (p = 0.006), therapist training (p = 0.002), therapist supervision (p = 0.009), and treatment fidelity monitoring (p = 0.003). There were no significant effects for differences in therapist experience, level of expertise in the treatment delivered, or nesting vs. crossing therapists in treatment arms. These findings demonstrate the substantial effect that decisions regarding control arm definition and implementation can have on RCT outcomes.

KW - Psychology

KW - Health sciences

KW - Control conditions

KW - Depression

KW - Meta-analysis

KW - Methodology

KW - Randomized controlled trial design

UR - http://www.scopus.com/inward/record.url?scp=84920624871&partnerID=8YFLogxK

U2 - 10.1007/s13142-014-0262-3

DO - 10.1007/s13142-014-0262-3

M3 - Scientific review articles

C2 - 25584090

VL - 4

SP - 407

EP - 423

JO - Translational Behavioral Medicine

JF - Translational Behavioral Medicine

SN - 1869-6716

IS - 4

ER -

DOI

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