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Accelerated dereplication of natural products, supported by reference libraries

Research output: Journal contributions › Journal articles › Research

Standard

Accelerated dereplication of natural products, supported by reference libraries. / Bitzer, Jens; Köpcke, Bärbel; Stadler, Marc et al.
In: Chimia, Vol. 61, No. 6, 27.06.2007, p. 332-338.

Research output: Journal contributions › Journal articles › Research

Harvard

Bitzer, J, Köpcke, B, Stadler, M, Hellwig, V, Ju, Y-M, Seip, S & Henkel, T 2007, 'Accelerated dereplication of natural products, supported by reference libraries', Chimia, vol. 61, no. 6, pp. 332-338. https://doi.org/10.2533/chimia.2007.332

APA

Bitzer, J., Köpcke, B., Stadler, M., Hellwig, V., Ju, Y.-M., Seip, S., & Henkel, T. (2007). Accelerated dereplication of natural products, supported by reference libraries. Chimia, 61(6), 332-338. https://doi.org/10.2533/chimia.2007.332

Vancouver

Bitzer J, Köpcke B, Stadler M, Hellwig V, Ju YM, Seip S et al. Accelerated dereplication of natural products, supported by reference libraries. Chimia. 2007 Jun 27;61(6):332-338. doi: 10.2533/chimia.2007.332

Bibtex

@article{175ac12a651147f79b874e442f909a55,
title = "Accelerated dereplication of natural products, supported by reference libraries",
abstract = "Natural products are an indispensable source for drug discovery. The major challenge for exploiting this evolutionary optimized pool of potential lead structures is the fast and reliable recognition of known compounds, i.e. dereplication. This task is essential for the discovery process in high-throughput screening scenarios, since it allows the focus to be placed on novel chemical structures at an early stage. Furthermore, information on identified compounds will help to rationalize observed bioactivities. This article describes an effective, library-supported strategy for the dereplication of crude extracts and pre-fractionated samples, using an HPLC-based multidetector platform and NMR techniques, respectively.",
keywords = "Chemistry, dereplication, multirdetector hplc, natural products, nmr, secondary metabolites, tandem mass spectrometry",
author = "Jens Bitzer and B{\"a}rbel K{\"o}pcke and Marc Stadler and Veronika Hellwig and Yu-Ming Ju and Stephan Seip and Thomas Henkel",
year = "2007",
month = jun,
day = "27",
doi = "10.2533/chimia.2007.332",
language = "English",
volume = "61",
pages = "332--338",
journal = "Chimia",
issn = "0009-4293",
publisher = "Swiss Chemical Society",
number = "6",

}

RIS

TY - JOUR

T1 - Accelerated dereplication of natural products, supported by reference libraries

AU - Bitzer, Jens

AU - Köpcke, Bärbel

AU - Stadler, Marc

AU - Hellwig, Veronika

AU - Ju, Yu-Ming

AU - Seip, Stephan

AU - Henkel, Thomas

PY - 2007/6/27

Y1 - 2007/6/27

N2 - Natural products are an indispensable source for drug discovery. The major challenge for exploiting this evolutionary optimized pool of potential lead structures is the fast and reliable recognition of known compounds, i.e. dereplication. This task is essential for the discovery process in high-throughput screening scenarios, since it allows the focus to be placed on novel chemical structures at an early stage. Furthermore, information on identified compounds will help to rationalize observed bioactivities. This article describes an effective, library-supported strategy for the dereplication of crude extracts and pre-fractionated samples, using an HPLC-based multidetector platform and NMR techniques, respectively.

AB - Natural products are an indispensable source for drug discovery. The major challenge for exploiting this evolutionary optimized pool of potential lead structures is the fast and reliable recognition of known compounds, i.e. dereplication. This task is essential for the discovery process in high-throughput screening scenarios, since it allows the focus to be placed on novel chemical structures at an early stage. Furthermore, information on identified compounds will help to rationalize observed bioactivities. This article describes an effective, library-supported strategy for the dereplication of crude extracts and pre-fractionated samples, using an HPLC-based multidetector platform and NMR techniques, respectively.

KW - Chemistry

KW - dereplication

KW - multirdetector hplc

KW - natural products

KW - nmr

KW - secondary metabolites

KW - tandem mass spectrometry

UR - http://www.scopus.com/inward/record.url?scp=34547280277&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/cdc1c88f-4dee-33c6-9d45-17ec4263b5da/

U2 - 10.2533/chimia.2007.332

DO - 10.2533/chimia.2007.332

M3 - Journal articles

VL - 61

SP - 332

EP - 338

JO - Chimia

JF - Chimia

SN - 0009-4293

IS - 6

ER -

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