Accelerated dereplication of natural products, supported by reference libraries
Publikation: Beiträge in Zeitschriften › Zeitschriftenaufsätze › Forschung
Standard
Accelerated dereplication of natural products, supported by reference libraries. / Bitzer, Jens; Köpcke, Bärbel; Stadler, Marc et al.
in: Chimia, Jahrgang 61, Nr. 6, 27.06.2007, S. 332-338.Publikation: Beiträge in Zeitschriften › Zeitschriftenaufsätze › Forschung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Accelerated dereplication of natural products, supported by reference libraries
AU - Bitzer, Jens
AU - Köpcke, Bärbel
AU - Stadler, Marc
AU - Hellwig, Veronika
AU - Ju, Yu-Ming
AU - Seip, Stephan
AU - Henkel, Thomas
PY - 2007/6/27
Y1 - 2007/6/27
N2 - Natural products are an indispensable source for drug discovery. The major challenge for exploiting this evolutionary optimized pool of potential lead structures is the fast and reliable recognition of known compounds, i.e. dereplication. This task is essential for the discovery process in high-throughput screening scenarios, since it allows the focus to be placed on novel chemical structures at an early stage. Furthermore, information on identified compounds will help to rationalize observed bioactivities. This article describes an effective, library-supported strategy for the dereplication of crude extracts and pre-fractionated samples, using an HPLC-based multidetector platform and NMR techniques, respectively.
AB - Natural products are an indispensable source for drug discovery. The major challenge for exploiting this evolutionary optimized pool of potential lead structures is the fast and reliable recognition of known compounds, i.e. dereplication. This task is essential for the discovery process in high-throughput screening scenarios, since it allows the focus to be placed on novel chemical structures at an early stage. Furthermore, information on identified compounds will help to rationalize observed bioactivities. This article describes an effective, library-supported strategy for the dereplication of crude extracts and pre-fractionated samples, using an HPLC-based multidetector platform and NMR techniques, respectively.
KW - Chemistry
KW - dereplication
KW - multirdetector hplc
KW - natural products
KW - nmr
KW - secondary metabolites
KW - tandem mass spectrometry
UR - http://www.scopus.com/inward/record.url?scp=34547280277&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/cdc1c88f-4dee-33c6-9d45-17ec4263b5da/
U2 - 10.2533/chimia.2007.332
DO - 10.2533/chimia.2007.332
M3 - Journal articles
VL - 61
SP - 332
EP - 338
JO - Chimia
JF - Chimia
SN - 0009-4293
IS - 6
ER -