Empowerment comes at a time when global competition and change require people to take initiative and be innovative. Based on the active, persistent, and change-oriented behaviors associated with psychological empowerment, the chapter states that empowerment can contribute to entrepreneurship. The dimensions of empowerment that suggest a theoretical and empirical link with entrepreneurial behavior are discussed. Several propositions regarding the interplay between empowerment and entrepreneurship are formulated. The chapter describes paths to promote empowerment and entrepreneurship in applied context and suggests future directions to advance research on empowerment in the field of entrepreneurship.