TY - JOUR

T1 - Sustainable Single-Stage Solid-Liquid Extraction of Hesperidin and Rutin from Agro-Products Using Cyrene

AU - Milescu, Roxana Alina

AU - Segatto, Mateus Lodi

AU - Stahl, Aylon

AU - Mcelroy, Con Robert

AU - Farmer, Thomas James

AU - Clark, James Hanley

AU - Zuin, Vânia Gomes

N1 - Publisher Copyright: © 2020 American Chemical Society.

PY - 2020/12/14

Y1 - 2020/12/14

N2 - Hesperidin and rutin are two sought-after natural flavonoids, traditionally extracted from abundant natural citrus fruits and tea leaves using large amounts of ethanol or methanol solvents. Recent trends in extractions have focused on minimizing the use of solvents and creating simpler cost-effective processes. This study aims to apply the concept of chemical valorization in the context of a circular economy, by using agro-industrial waste and biobased alternatives to traditional solvents, which are of environmental concern. We use minimum amounts of solvent/sample (5 mL/0.25 or 0.5 g) to extract hesperidin and rutin in a single-stage solid-liquid extraction. Thirty individual solvents and HSPiP were applied to find the best solvents/blends for extraction. The type of solvent, sample preparation, maceration time, and extraction temperature were studied. Results showed that the biobased solvent Cyrene is very effective when mildly heated to 65 °C (up to 91%) or mixed with water. Adding water to Cyrene forms its geminal diol hydrate, this enhances the solubility and extraction of hesperidin and rutin up to ten times than those of the original pure ketone form. Quantitative sustainability metrics from the CHEM21 Toolkit demonstrated that our extraction methodology is environmentally friendly and offers future potential of isolation of other flavonoids.

AB - Hesperidin and rutin are two sought-after natural flavonoids, traditionally extracted from abundant natural citrus fruits and tea leaves using large amounts of ethanol or methanol solvents. Recent trends in extractions have focused on minimizing the use of solvents and creating simpler cost-effective processes. This study aims to apply the concept of chemical valorization in the context of a circular economy, by using agro-industrial waste and biobased alternatives to traditional solvents, which are of environmental concern. We use minimum amounts of solvent/sample (5 mL/0.25 or 0.5 g) to extract hesperidin and rutin in a single-stage solid-liquid extraction. Thirty individual solvents and HSPiP were applied to find the best solvents/blends for extraction. The type of solvent, sample preparation, maceration time, and extraction temperature were studied. Results showed that the biobased solvent Cyrene is very effective when mildly heated to 65 °C (up to 91%) or mixed with water. Adding water to Cyrene forms its geminal diol hydrate, this enhances the solubility and extraction of hesperidin and rutin up to ten times than those of the original pure ketone form. Quantitative sustainability metrics from the CHEM21 Toolkit demonstrated that our extraction methodology is environmentally friendly and offers future potential of isolation of other flavonoids.

KW - circular economy

KW - Cyrene

KW - green chemistry

KW - solid-liquid extraction

KW - sustainable chemistry

KW - sustainable extraction

KW - Chemistry

UR - http://www.scopus.com/inward/record.url?scp=85097751973&partnerID=8YFLogxK

U2 - 10.1021/acssuschemeng.0c06751

DO - 10.1021/acssuschemeng.0c06751

M3 - Journal articles

AN - SCOPUS:85097751973

VL - 8

SP - 18245

EP - 18257

JO - ACS Sustainable Chemistry & Engineering

JF - ACS Sustainable Chemistry & Engineering

SN - 2168-0485

IS - 49

ER -