Education and learning take place in a situation that is heavily influenced by the culture. The learners’ cultural context affects cognitive processes in learning. Hence, to improve the conditions for learning, e-learning environments and their contents have to interact with the learner in a culturally appropriate way. Therefore, an e-learning system intended for cross-cultural usage has to adapt to the students’ diverse cultural background. For the enculturation of the European platform for mathematics learning, ActiveMath, a number of dimensions are adapted culturally. These are: presentation of system and learning material, terminology, selection and sequencing of learning objects, interaction, and learning scenarios. This chapter describes ActiveMath’ enculturation: computational model, computational techniques, and the empirical basis for the cultural adaptation.