Therapeutic drug monitoring of posaconazole in hematology patients: experience with a new high-performance liquid chromatography-based method
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In: Antimicrobial Agents and Chemotherapy, Vol. 54, No. 9, 09.2010, p. 4029-4032.
Research output: Journal contributions › Journal articles › Research › peer-review
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TY - JOUR
T1 - Therapeutic drug monitoring of posaconazole in hematology patients: experience with a new high-performance liquid chromatography-based method
AU - Neubauer, Werner Christian
AU - Engelhardt, Monika
AU - König, Armin
AU - Hieke, Stefanie
AU - Jung, Manfred
AU - Bertz, Hartmut
AU - Kümmerer, Klaus
PY - 2010/9
Y1 - 2010/9
N2 - Parallel administration of the proton pump inhibitor (PPI) esomeprazole has been shown to decrease oral bioavailability of posaconazole in healthy volunteers. We prospectively analyzed serum samples (n = 59) obtained from hematology patients (n = 27) under posaconazole prophylaxis. Patients treated concomitantly with pantoprazole had significantly lower posaconazole levels than patients without PPI treatment (median levels of 630 μg/liter versus 1,125 μg/liter, respectively). These results suggest that drug monitoring is relevant when posaconazole and pantoprazole are administered concomitantly. Copyright © 2010, American Society for Microbiology. All Rights Reserved.
AB - Parallel administration of the proton pump inhibitor (PPI) esomeprazole has been shown to decrease oral bioavailability of posaconazole in healthy volunteers. We prospectively analyzed serum samples (n = 59) obtained from hematology patients (n = 27) under posaconazole prophylaxis. Patients treated concomitantly with pantoprazole had significantly lower posaconazole levels than patients without PPI treatment (median levels of 630 μg/liter versus 1,125 μg/liter, respectively). These results suggest that drug monitoring is relevant when posaconazole and pantoprazole are administered concomitantly. Copyright © 2010, American Society for Microbiology. All Rights Reserved.
KW - Chemistry
KW - Adult
KW - Aged
KW - Antifungal Agents
KW - Chromatography, High Pressure Liquid
KW - Female
KW - Hematologic Neoplasms
KW - Humans
KW - Male
KW - Middle Aged
KW - Mycoses
KW - Prospective Studies
KW - Triazoles
UR - http://www.scopus.com/inward/record.url?scp=77956122820&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/ddfbf767-8284-3f5d-99ee-36156fbeae27/
U2 - 10.1128/AAC.00150-10
DO - 10.1128/AAC.00150-10
M3 - Journal articles
C2 - 20547790
VL - 54
SP - 4029
EP - 4032
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 1098-6596
IS - 9
ER -