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Therapeutic drug monitoring of posaconazole in hematology patients: experience with a new high-performance liquid chromatography-based method

Research output: Journal contributions › Journal articles › Research › peer-review

Standard

Therapeutic drug monitoring of posaconazole in hematology patients: experience with a new high-performance liquid chromatography-based method. / Neubauer, Werner Christian; Engelhardt, Monika; König, Armin et al.
In: Antimicrobial Agents and Chemotherapy, Vol. 54, No. 9, 09.2010, p. 4029-4032.

Research output: Journal contributions › Journal articles › Research › peer-review

Harvard

Neubauer, WC, Engelhardt, M, König, A, Hieke, S, Jung, M, Bertz, H & Kümmerer, K 2010, 'Therapeutic drug monitoring of posaconazole in hematology patients: experience with a new high-performance liquid chromatography-based method', Antimicrobial Agents and Chemotherapy, vol. 54, no. 9, pp. 4029-4032. https://doi.org/10.1128/AAC.00150-10

APA

Neubauer, W. C., Engelhardt, M., König, A., Hieke, S., Jung, M., Bertz, H., & Kümmerer, K. (2010). Therapeutic drug monitoring of posaconazole in hematology patients: experience with a new high-performance liquid chromatography-based method. Antimicrobial Agents and Chemotherapy, 54(9), 4029-4032. https://doi.org/10.1128/AAC.00150-10

Vancouver

Neubauer WC, Engelhardt M, König A, Hieke S, Jung M, Bertz H et al. Therapeutic drug monitoring of posaconazole in hematology patients: experience with a new high-performance liquid chromatography-based method. Antimicrobial Agents and Chemotherapy. 2010 Sept;54(9):4029-4032. doi: 10.1128/AAC.00150-10

Bibtex

@article{ed6522367c874d37bc534e2f3584c839,
title = "Therapeutic drug monitoring of posaconazole in hematology patients: experience with a new high-performance liquid chromatography-based method",
abstract = "Parallel administration of the proton pump inhibitor (PPI) esomeprazole has been shown to decrease oral bioavailability of posaconazole in healthy volunteers. We prospectively analyzed serum samples (n = 59) obtained from hematology patients (n = 27) under posaconazole prophylaxis. Patients treated concomitantly with pantoprazole had significantly lower posaconazole levels than patients without PPI treatment (median levels of 630 μg/liter versus 1,125 μg/liter, respectively). These results suggest that drug monitoring is relevant when posaconazole and pantoprazole are administered concomitantly. Copyright {\textcopyright} 2010, American Society for Microbiology. All Rights Reserved.",
keywords = "Chemistry, Adult, Aged, Antifungal Agents, Chromatography, High Pressure Liquid, Female, Hematologic Neoplasms, Humans, Male, Middle Aged, Mycoses, Prospective Studies, Triazoles",
author = "Neubauer, {Werner Christian} and Monika Engelhardt and Armin K{\"o}nig and Stefanie Hieke and Manfred Jung and Hartmut Bertz and Klaus K{\"u}mmerer",
year = "2010",
month = sep,
doi = "10.1128/AAC.00150-10",
language = "English",
volume = "54",
pages = "4029--4032",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "1098-6596",
publisher = "American Society For Microbiology",
number = "9",

}

RIS

TY - JOUR

T1 - Therapeutic drug monitoring of posaconazole in hematology patients: experience with a new high-performance liquid chromatography-based method

AU - Neubauer, Werner Christian

AU - Engelhardt, Monika

AU - König, Armin

AU - Hieke, Stefanie

AU - Jung, Manfred

AU - Bertz, Hartmut

AU - Kümmerer, Klaus

PY - 2010/9

Y1 - 2010/9

N2 - Parallel administration of the proton pump inhibitor (PPI) esomeprazole has been shown to decrease oral bioavailability of posaconazole in healthy volunteers. We prospectively analyzed serum samples (n = 59) obtained from hematology patients (n = 27) under posaconazole prophylaxis. Patients treated concomitantly with pantoprazole had significantly lower posaconazole levels than patients without PPI treatment (median levels of 630 μg/liter versus 1,125 μg/liter, respectively). These results suggest that drug monitoring is relevant when posaconazole and pantoprazole are administered concomitantly. Copyright © 2010, American Society for Microbiology. All Rights Reserved.

AB - Parallel administration of the proton pump inhibitor (PPI) esomeprazole has been shown to decrease oral bioavailability of posaconazole in healthy volunteers. We prospectively analyzed serum samples (n = 59) obtained from hematology patients (n = 27) under posaconazole prophylaxis. Patients treated concomitantly with pantoprazole had significantly lower posaconazole levels than patients without PPI treatment (median levels of 630 μg/liter versus 1,125 μg/liter, respectively). These results suggest that drug monitoring is relevant when posaconazole and pantoprazole are administered concomitantly. Copyright © 2010, American Society for Microbiology. All Rights Reserved.

KW - Chemistry

KW - Adult

KW - Aged

KW - Antifungal Agents

KW - Chromatography, High Pressure Liquid

KW - Female

KW - Hematologic Neoplasms

KW - Humans

KW - Male

KW - Middle Aged

KW - Mycoses

KW - Prospective Studies

KW - Triazoles

UR - http://www.scopus.com/inward/record.url?scp=77956122820&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/ddfbf767-8284-3f5d-99ee-36156fbeae27/

U2 - 10.1128/AAC.00150-10

DO - 10.1128/AAC.00150-10

M3 - Journal articles

C2 - 20547790

VL - 54

SP - 4029

EP - 4032

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 1098-6596

IS - 9

ER -

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