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Therapeutic drug monitoring of posaconazole in hematology patients: experience with a new high-performance liquid chromatography-based method

Research output: Journal contributions › Journal articles › Research › peer-review

Authors

  • Werner Christian Neubauer
  • Monika Engelhardt
  • Armin König
  • Stefanie Hieke
  • Manfred Jung
  • Hartmut Bertz
  • Klaus Kümmerer
Parallel administration of the proton pump inhibitor (PPI) esomeprazole has been shown to decrease oral bioavailability of posaconazole in healthy volunteers. We prospectively analyzed serum samples (n = 59) obtained from hematology patients (n = 27) under posaconazole prophylaxis. Patients treated concomitantly with pantoprazole had significantly lower posaconazole levels than patients without PPI treatment (median levels of 630 μg/liter versus 1,125 μg/liter, respectively). These results suggest that drug monitoring is relevant when posaconazole and pantoprazole are administered concomitantly. Copyright © 2010, American Society for Microbiology. All Rights Reserved.
Original languageEnglish
JournalAntimicrobial Agents and Chemotherapy
Volume54
Issue number9
Pages (from-to)4029-4032
Number of pages4
DOIs
Publication statusPublished - 09.2010
Externally publishedYes

    Research areas

  • Chemistry - Adult, Aged, Antifungal Agents, Chromatography, High Pressure Liquid, Female, Hematologic Neoplasms, Humans, Male, Middle Aged, Mycoses, Prospective Studies, Triazoles

Other publications by the same author(s)

Accelerating the industrial transition with safe-and-sustainable-by-design (SSbD)

Soeteman-Hernández, L. G., Tickner, J. A., Dierckx, A., Kümmerer, K., Apel, C. & Strömberg, E., 17.02.2025, (E-pub ahead of print) In: RSC Sustainability. 7 p.

Research output: Journal contributions › Scientific review articles › Research

Eco-pharma dilemma: Navigating environmental sustainability trade-offs within the lifecycle of pharmaceuticals – A comment

Moermond, C. T. A., Puhlmann, N., Pieters, L., Matharu, A., Boone, L., Dobbelaere, M., Proquin, H., Kümmerer, K., Ragas, A. M. J., Vidaurre, R., Venhuis, B. & De Smedt, D., 01.02.2025, In: Sustainable Chemistry and Pharmacy. 43, 10 p., 101893.

Research output: Journal contributions › Journal articles › Research › peer-review

Green chemistry and sustainable chemistry related to water challenges: Solutions and prospects in a changing climate

Mahjoub, B., Fersi, C., Bouteffeha, M. & Kümmerer, K., 01.04.2025, In: Current Opinion in Green and Sustainable Chemistry. 52, 11 p., 101000.

Research output: Journal contributions › Scientific review articles › Research

Inventing a secure future: material stewardship as chemistry's mission for sustainability

Matlin, S. A., Cornell, S. E., Kümmerer, K., Mahaffy, P. G. & Mehta, G., 14.01.2025, In: RSC Sustainability. 3, 2, p. 804-821 18 p., d4su00576g.

Research output: Journal contributions › Scientific review articles › Research

The complex spatio-temporal dynamics of organic micropollutants in tidal rivers

Schneider, J. R. L., Kümmerer, K., Logemann, J. & Radke, M., 01.03.2025, In: Chemosphere. 373, 10 p., 144180.

Research output: Journal contributions › Journal articles › Research › peer-review

DOI

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