Simultaneous Determination of 11 Sulfonamides by HPLC–UV and Application for Fast Screening of Their Aerobic Elimination and Biodegradation in a Simple Test

Research output: Journal contributionsJournal articlesResearchpeer-review

Standard

Simultaneous Determination of 11 Sulfonamides by HPLC–UV and Application for Fast Screening of Their Aerobic Elimination and Biodegradation in a Simple Test. / Mahmoud, Waleed M. M.; Khaleel, Nareman Dahshan Henedaq; Hadad, Ghada M. et al.
In: Clean - Soil, Air, Water, Vol. 41, No. 9, 09.2013, p. 907-916.

Research output: Journal contributionsJournal articlesResearchpeer-review

Harvard

APA

Vancouver

Bibtex

@article{b96b5bf85c1f49e6ab74bf011ab968a6,
title = "Simultaneous Determination of 11 Sulfonamides by HPLC–UV and Application for Fast Screening of Their Aerobic Elimination and Biodegradation in a Simple Test",
abstract = "Sulfonamides (SAs) are one of the most frequently used antibiotics. SAs have been found in various environmental compartments. If SAs are not degraded in the environment, they can affect bacteria by their antibiotic properties and contribute to bacterial antibiotic resistance. Therefore, the biodegradability of 11 SAs (sulfanilamide, sulfaguanidine monohydrate, sulfadiazine, sulfathiazole, sulfapyridine, sulfamerazine, sulfamethoxypyridazine, sulfachloropyridazine, sulfamethazine, sulfamethoxazole, and sulfadimethoxine) was studied. For this purpose, the Closed Bottle Test (CBT, OECD 301D) was performed, which includes a toxicity control. In order to monitor the environmental fate of the parent compound and to check for transformation products, a simple, efficient, and reliable HPLC-UV method for the simultaneous determination of these SAs has been developed. Acetonitrile and water (with 0.1% formic acid) were used as mobile phase solvents for gradient elution. The method was validated in terms of precision, detection and quantitation limits, selectivity, and analytical solution stability. In the CBT, none of these SAs was readily biodegradable. The HPLC-UV analysis confirmed that no degradation of any SA took place. In the toxicity control, these SAs showed no toxic effect in the used concentration of environmental bacteria applied in the test.",
keywords = "Chemistry, Biodegradation, Environmental, Antibiotics, Closed Bottle Test, Aerobic biodegradation, Aquatic environment, HPLC, Sustainability Science",
author = "Mahmoud, {Waleed M. M.} and Khaleel, {Nareman Dahshan Henedaq} and Hadad, {Ghada M.} and Abdel-Salam, {Randa A} and Annette Hai{\ss} and Klaus K{\"u}mmerer",
year = "2013",
month = sep,
doi = "10.1002/clen.201200508",
language = "English",
volume = "41",
pages = "907--916",
journal = "Clean - Soil, Air, Water",
issn = "1863-0669",
publisher = "Wiley-VCH Verlag",
number = "9",

}

RIS

TY - JOUR

T1 - Simultaneous Determination of 11 Sulfonamides by HPLC–UV and Application for Fast Screening of Their Aerobic Elimination and Biodegradation in a Simple Test

AU - Mahmoud, Waleed M. M.

AU - Khaleel, Nareman Dahshan Henedaq

AU - Hadad, Ghada M.

AU - Abdel-Salam, Randa A

AU - Haiß, Annette

AU - Kümmerer, Klaus

PY - 2013/9

Y1 - 2013/9

N2 - Sulfonamides (SAs) are one of the most frequently used antibiotics. SAs have been found in various environmental compartments. If SAs are not degraded in the environment, they can affect bacteria by their antibiotic properties and contribute to bacterial antibiotic resistance. Therefore, the biodegradability of 11 SAs (sulfanilamide, sulfaguanidine monohydrate, sulfadiazine, sulfathiazole, sulfapyridine, sulfamerazine, sulfamethoxypyridazine, sulfachloropyridazine, sulfamethazine, sulfamethoxazole, and sulfadimethoxine) was studied. For this purpose, the Closed Bottle Test (CBT, OECD 301D) was performed, which includes a toxicity control. In order to monitor the environmental fate of the parent compound and to check for transformation products, a simple, efficient, and reliable HPLC-UV method for the simultaneous determination of these SAs has been developed. Acetonitrile and water (with 0.1% formic acid) were used as mobile phase solvents for gradient elution. The method was validated in terms of precision, detection and quantitation limits, selectivity, and analytical solution stability. In the CBT, none of these SAs was readily biodegradable. The HPLC-UV analysis confirmed that no degradation of any SA took place. In the toxicity control, these SAs showed no toxic effect in the used concentration of environmental bacteria applied in the test.

AB - Sulfonamides (SAs) are one of the most frequently used antibiotics. SAs have been found in various environmental compartments. If SAs are not degraded in the environment, they can affect bacteria by their antibiotic properties and contribute to bacterial antibiotic resistance. Therefore, the biodegradability of 11 SAs (sulfanilamide, sulfaguanidine monohydrate, sulfadiazine, sulfathiazole, sulfapyridine, sulfamerazine, sulfamethoxypyridazine, sulfachloropyridazine, sulfamethazine, sulfamethoxazole, and sulfadimethoxine) was studied. For this purpose, the Closed Bottle Test (CBT, OECD 301D) was performed, which includes a toxicity control. In order to monitor the environmental fate of the parent compound and to check for transformation products, a simple, efficient, and reliable HPLC-UV method for the simultaneous determination of these SAs has been developed. Acetonitrile and water (with 0.1% formic acid) were used as mobile phase solvents for gradient elution. The method was validated in terms of precision, detection and quantitation limits, selectivity, and analytical solution stability. In the CBT, none of these SAs was readily biodegradable. The HPLC-UV analysis confirmed that no degradation of any SA took place. In the toxicity control, these SAs showed no toxic effect in the used concentration of environmental bacteria applied in the test.

KW - Chemistry

KW - Biodegradation, Environmental

KW - Antibiotics

KW - Closed Bottle Test

KW - Aerobic biodegradation

KW - Aquatic environment

KW - HPLC

KW - Sustainability Science

UR - http://www.scopus.com/inward/record.url?scp=84883410473&partnerID=8YFLogxK

U2 - 10.1002/clen.201200508

DO - 10.1002/clen.201200508

M3 - Journal articles

VL - 41

SP - 907

EP - 916

JO - Clean - Soil, Air, Water

JF - Clean - Soil, Air, Water

SN - 1863-0669

IS - 9

ER -

DOI

Recently viewed

Publications

  1. Armut über Generationen. Überlegungen zur methodischen Vorgehensweise in der rekonstruktiven intergenerationalen Ungleichheitsforschung und eine fallexemplarische Analyse
  2. How accurate are drivers' predictions of their own mobility? Accounting for psychological factors in the development of intelligent charging technology for electric vehicles
  3. Ökonomie und Literatur – Einsatzmöglichkeiten von Johann Wolfgang von Goethes ‚Faust II’ für die sozioökonomische Bildung und den betriebswirtschaftlich-kaufmännischen Unterricht
  4. Gesucht: Resonanzräume für Wahrnehmung und Erkennen in der Berufsbildung für nachhaltige Entwicklung in der sozio-ökonomischen Bildung. Vom "Wahrnehmen-Müssen" zum "Mehr-wahrnehmen-Können"
  5. Fritz K. Ringer, Felder des Wissens: Bildung, Wissenschaft und sozialer Aufstieg in Frankreich und Deutschland um 1900, Weinheim: Deutscher Studien Verlag 2003 (373 Seiten; ISBN 3-407-32049-X)
  6. Peter Neumann/Denise Renger (Hrsg) Sachunmittelbare Demokratie im interdisziplinären und internationalen Kontext 2008/09 (Nomos). Christina Eder Direkte Demokratie auf subnationaler Ebene. (Nomos)
  7. Operation Video, eine Technik des Nahsehens und ihr spezifisches Subjekt: die Videokünstlerin der 1970er Jahre : From BetaMax to Blockbuster, video stores and the invention of movies on video
  8. Kulick, Andreas/Goldhammer, Michael (Hrsg.): Der Terrorist als Feind? – Personalisierung im Polizei- und Völkerrecht, Beiträge zum Sicherheitsrecht und zur Sicherheitspolitik, Bd.5. Tübingen: MohrSiebeck, 2020.
  9. „Resonanzräume des Subpolitischen“ als wirtschaftsdidaktische Antwort auf ökonomisierte (wirtschafts-)betriebliche Lebenssituationen – eine Forschungsheuristik vor dem Hintergrund der Nachhaltigkeitsidee
  10. Stellungnahme der AG Methoden der gesundheitsökonomischen Evaluation (AG MEG) in der Deutschen Gesellschaft für Sozialmedizin und Prävention (DGSMP) zum 1. Entwurf des IQWiG Methodenpapiers zur Kosten-Nutzen-Bewertung von Arzneimitteln
  11. Krankheit, Sterben und Tod im Leben und Schreiben europäischer Schriftsteller. Ed. Roland Berbig, Richard Faber und Christof Müller-Busch. Bd. 1: Das 18. und 19. Jahrhundert. Bd. 2: Das 20. und 21. Jahrhundert. Würzburg: Königshausen & Neumann, 2017.