Parametric finite element model and mechanical characterisation of electrospun materials for biomedical applications

Research output: Journal contributionsJournal articlesResearchpeer-review

Authors

Electrospun materials, due to their unique properties, have found many applications in the biomedical field. Exploiting their porous nanofibrous structure, they are often used as scaffolds in tissue engineering which closely resemble a native cellular environment. The structural and mechanical properties of the substrates need to be carefully optimised to mimic cues used by the extracellular matrix to guide cells’ behaviour and improve existing scaffolds. Optimisation of these parameters is enabled by using the finite element model of electrospun structures proposed in this study. First, a fully parametric three-dimensional microscopic model of electrospun material with a random fibrous network was developed. Experimental results were obtained by testing electrospun poly(ethylene) oxide materials. Parameters of single fibres were determined by atomic force microscopy nanoindentations and used as input data for the model. The validation was performed by comparing model output data with tensile test results obtained for electrospun mats. We performed extensive analysis of model parameters correlations to understand the crucial factors and enable extrapolation of a simplified model. We found good agreement between the simulation and the experimental data. The proposed model is a potent tool in the optimisation of electrospun structures and scaffolds for enhanced regenerative therapies.

Original languageEnglish
Article number278
JournalMaterials
Volume14
Issue number2
Pages (from-to)1-15
Number of pages15
ISSN1996-1944
DOIs
Publication statusPublished - 07.01.2021

Bibliographical note

Funding Information:
Short Term Scientific Mission was funded by European Commission via FP7 COST Action 1206.I would like to acknowledge COST Action 1206 ?Electrospun Nano-fibres for bio inspired composite materials and innovative industrial applications? for allowing me to realize validation part of this work at VTT Technical Research Centre of Finland Ltd.; and VTT for hosting this Short Term Scientific Mission.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

    Research areas

  • Electrospinning, FE, Modelling, Nonwoven, Poly(ethylene oxide) (PEO), Tensile testing
  • Engineering

Documents

DOI

Recently viewed

Publications

  1. Web-scale extension of RDF knowledge bases from templated websites
  2. Kalman Filter for Predictive Maintenance and Anomaly Detection
  3. Scale-dependent diversity patterns affect spider assemblages of two contrasting forest ecosystems
  4. The Creation of the Concept through the Interaction of Philosophy with Science and Art
  5. Understanding and Supporting Management Decision-Making
  6. Object-Oriented Construction Handbook
  7. A geometric approach for the design and control of an electromagnetic actuator to optimize its dynamic performance
  8. Effect of thermo-mechanical conditions during constrained friction processing on the particle refinement of AM50 Mg-alloy phases
  9. Bridging the Gap: Generating a Comprehensive Biomedical Knowledge Graph Question Answering Dataset
  10. Modelling biodegradability based on OECD 301D data for the design of mineralising ionic liquids
  11. Reading Comprehension as Embodied Action: Exploratory Findings on Nonlinear Eye Movement Dynamics and Comprehension of Scientific Texts
  12. Performance of methods to select landscape metrics for modelling species richness
  13. Determination of the construction and the material identity values of outside building components with the help of in-situ measuring procedures and FEM-simulation calculations
  14. DISKNET – A Platform for the Systematic Accumulation of Knowledge in IS Research
  15. A Sensitive Microsystem as Biosensor for Cell Growth Monitoring and Antibiotic Testing
  16. Experimental investigation of the fluid-structure interaction during deep drawing of fiber metal laminates in the in-situ hybridization process
  17. The Role of Output Vocabulary in T2T LMs for SPARQL Semantic Parsing
  18. Late developers and the inequity of "equitable utilization" and the harm of "do no harm"
  19. The impact of goal focus, task type and group size on synchronous net-based collaborative learning discourses
  20. Differences in adjustment flexibility between regular and temporary agency work
  21. Mechanical characterization of as-cast AA7075/6060 and CuSn6/Cu99.5 compounds using an experimental and numerical push-out test
  22. Integrating errors into the training process
  23. Dichotomy or continuum? A global review of the interaction between autonomous and planned adaptations
  24. Lost-customers approximation of semi-open queueing networks with backordering
  25. Quality System Development at the University of Graz
  26. Collaborative benchmarking of functional-structural root architecture models
  27. Unlocking knowledge-policy action gaps in disaster-recovery-risk governance cycle
  28. Variational pragmatics in the foreign language classroom