Novel analgesic triglycerides from cultures of Agaricus macrosporus and other basidiomycetes as selective inhibitors of neurolysin

Research output: Journal contributionsJournal articlesResearch

Standard

Novel analgesic triglycerides from cultures of Agaricus macrosporus and other basidiomycetes as selective inhibitors of neurolysin. / Stadler, Marc; Hellwig, Veronika; Mayer-Bartschmid, Anke et al.
In: Journal of Antibiotics, Vol. 58, No. 12, 01.12.2005, p. 775-786.

Research output: Journal contributionsJournal articlesResearch

Harvard

APA

Vancouver

Stadler M, Hellwig V, Mayer-Bartschmid A, Denzer D, Wiese B, Burkhardt N. Novel analgesic triglycerides from cultures of Agaricus macrosporus and other basidiomycetes as selective inhibitors of neurolysin. Journal of Antibiotics. 2005 Dec 1;58(12):775-786. doi: 10.1038/ja.2005.105

Bibtex

@article{153f11eed94a43a390d02a8e3d87b419,
title = "Novel analgesic triglycerides from cultures of Agaricus macrosporus and other basidiomycetes as selective inhibitors of neurolysin",
abstract = "The agaricoglycerides are a new class of fungal secondary metabolites that constitute esters of chlorinated 4-hydroxy benzoic acid and glycerol. They are produced in cultures of the edible mushroom, Agaricus macrosporus, and several other basidiomycetes of the genera Agaricus, Hypholoma, Psathyrella and Stropharia. The main active principle, agaricoglyceride A, showed strong activities against neurolysin, a protease involved in the regulation of dynorphin and neurotensin metabolism (IC 50=200 nM), and even exhibited moderate analgesic in vivo activities in an in vivo model. Agaricoglyceride monoacetates (IC 50=50 nM) showed even stronger in vitro activities. Several further co-metabolites with weaker or lacking bioactivities were also obtained and characterized. Among those were further agaricoglyceride derivatives, as well as further chlorinated phenol derivatives such as the new compound, agaricic ester. The characteristics of the producer organisms, the isolation of bioactive metabolites from cultures of A. macrosporus, their biological activities, and preliminary results on their occurrence in basidiomycetes, are described.",
keywords = "Chemistry, agaricoglycerides, fermentation, fungi, in vivo activity",
author = "Marc Stadler and Veronika Hellwig and Anke Mayer-Bartschmid and Dirk Denzer and Burkhard Wiese and Nils Burkhardt",
year = "2005",
month = dec,
day = "1",
doi = "10.1038/ja.2005.105",
language = "English",
volume = "58",
pages = "775--786",
journal = "Journal of Antibiotics",
issn = "0021-8820",
publisher = "Nature Publishing Group",
number = "12",

}

RIS

TY - JOUR

T1 - Novel analgesic triglycerides from cultures of Agaricus macrosporus and other basidiomycetes as selective inhibitors of neurolysin

AU - Stadler, Marc

AU - Hellwig, Veronika

AU - Mayer-Bartschmid, Anke

AU - Denzer, Dirk

AU - Wiese, Burkhard

AU - Burkhardt, Nils

PY - 2005/12/1

Y1 - 2005/12/1

N2 - The agaricoglycerides are a new class of fungal secondary metabolites that constitute esters of chlorinated 4-hydroxy benzoic acid and glycerol. They are produced in cultures of the edible mushroom, Agaricus macrosporus, and several other basidiomycetes of the genera Agaricus, Hypholoma, Psathyrella and Stropharia. The main active principle, agaricoglyceride A, showed strong activities against neurolysin, a protease involved in the regulation of dynorphin and neurotensin metabolism (IC 50=200 nM), and even exhibited moderate analgesic in vivo activities in an in vivo model. Agaricoglyceride monoacetates (IC 50=50 nM) showed even stronger in vitro activities. Several further co-metabolites with weaker or lacking bioactivities were also obtained and characterized. Among those were further agaricoglyceride derivatives, as well as further chlorinated phenol derivatives such as the new compound, agaricic ester. The characteristics of the producer organisms, the isolation of bioactive metabolites from cultures of A. macrosporus, their biological activities, and preliminary results on their occurrence in basidiomycetes, are described.

AB - The agaricoglycerides are a new class of fungal secondary metabolites that constitute esters of chlorinated 4-hydroxy benzoic acid and glycerol. They are produced in cultures of the edible mushroom, Agaricus macrosporus, and several other basidiomycetes of the genera Agaricus, Hypholoma, Psathyrella and Stropharia. The main active principle, agaricoglyceride A, showed strong activities against neurolysin, a protease involved in the regulation of dynorphin and neurotensin metabolism (IC 50=200 nM), and even exhibited moderate analgesic in vivo activities in an in vivo model. Agaricoglyceride monoacetates (IC 50=50 nM) showed even stronger in vitro activities. Several further co-metabolites with weaker or lacking bioactivities were also obtained and characterized. Among those were further agaricoglyceride derivatives, as well as further chlorinated phenol derivatives such as the new compound, agaricic ester. The characteristics of the producer organisms, the isolation of bioactive metabolites from cultures of A. macrosporus, their biological activities, and preliminary results on their occurrence in basidiomycetes, are described.

KW - Chemistry

KW - agaricoglycerides

KW - fermentation

KW - fungi

KW - in vivo activity

UR - http://www.scopus.com/inward/record.url?scp=31444435431&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/2bb31ecf-e842-31e4-bba4-c409bd3411de/

U2 - 10.1038/ja.2005.105

DO - 10.1038/ja.2005.105

M3 - Journal articles

VL - 58

SP - 775

EP - 786

JO - Journal of Antibiotics

JF - Journal of Antibiotics

SN - 0021-8820

IS - 12

ER -

DOI