Low flows of the Ilmenau River (1434 km²) in northwest Germany have decreased by about 25% over the last 50 years. In the same period, moderate climate changes have taken place and annual groundwater abstractions for sprinkler irrigation have increased by up to 50 hm³ (million m³), with a strong variation due to the respective prevailing weather conditions. Time-series analyses with multiple regression analysis allow detecting and quantifying different influences on low flows. It is also shown that farmers allocate irrigation water volumes carefully according to seasonal precipitation and temperatures. Decline of groundwater levels in summer and the low flow situation are aggravated by the cumulative effect of higher irrigation in drier years. Groundwater recharge and recovery of the water table have been observed subsequently during the winter season.