Spray-dried chitosan-metal microparticles for ciprofloxacin adsorption: Kinetic and equilibrium studies
Publikation: Beiträge in Zeitschriften › Zeitschriftenaufsätze › Forschung › begutachtet
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in: Soft Matter, Jahrgang 7, Nr. 16, 21.08.2011, S. 7304-7312.
Publikation: Beiträge in Zeitschriften › Zeitschriftenaufsätze › Forschung › begutachtet
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TY - JOUR
T1 - Spray-dried chitosan-metal microparticles for ciprofloxacin adsorption
T2 - Kinetic and equilibrium studies
AU - Reynaud, Franceline
AU - Tsapis, Nicolas
AU - Deyme, Michel
AU - Vasconcelos, Tibiriça G.
AU - Gueutin, Claire
AU - Guterres, Sílvia S.
AU - Pohlmann, Adriana R.
AU - Fattal , Elias
PY - 2011/8/21
Y1 - 2011/8/21
N2 - Chitosan, a natural polysaccharide obtained from chitin deacetylation, complexes with metal ions by coordination with the free electron pairs of amine groups. Based on this complexation mechanism, cross-linked chitosan-metal microparticles were prepared by spray drying using iron (II or III) or zinc ions and characterized in terms of size distribution and capacity to specifically adsorb ciprofloxacin. Chitosan-Zn(II) and chitosan-Fe(III) microparticles appear to adsorb more ciprofloxacin than plain chitosan or chitosan-Fe(II) microparticles. Adsorption isotherms for CH and CH–Fe(II) microparticles can be fitted by a single logarithm model (slope 1) with one ciprofloxacin per adsorption site, whereas for CH–Fe(II) and CH–Zn(II) microparticles, isotherms are bilogarithmic with an initial slope of 2, suggesting that a single adsorption site can bind two molecules of ciprofloxacin. In addition, the pseudo second order kinetic model fits well experimental data, proving that adsorption is mediated by a chemical reaction. CH–Fe(II) and CH–Zn(II) appear very promising for drug elimination, either from hospital waste water or from the gastrointestinal tract to prevent the emergence of antibiotic resistance.
AB - Chitosan, a natural polysaccharide obtained from chitin deacetylation, complexes with metal ions by coordination with the free electron pairs of amine groups. Based on this complexation mechanism, cross-linked chitosan-metal microparticles were prepared by spray drying using iron (II or III) or zinc ions and characterized in terms of size distribution and capacity to specifically adsorb ciprofloxacin. Chitosan-Zn(II) and chitosan-Fe(III) microparticles appear to adsorb more ciprofloxacin than plain chitosan or chitosan-Fe(II) microparticles. Adsorption isotherms for CH and CH–Fe(II) microparticles can be fitted by a single logarithm model (slope 1) with one ciprofloxacin per adsorption site, whereas for CH–Fe(II) and CH–Zn(II) microparticles, isotherms are bilogarithmic with an initial slope of 2, suggesting that a single adsorption site can bind two molecules of ciprofloxacin. In addition, the pseudo second order kinetic model fits well experimental data, proving that adsorption is mediated by a chemical reaction. CH–Fe(II) and CH–Zn(II) appear very promising for drug elimination, either from hospital waste water or from the gastrointestinal tract to prevent the emergence of antibiotic resistance.
KW - Chemistry
KW - Biology
KW - Ciprofoloxacin
KW - Sustainability Science
UR - http://www.scopus.com/inward/record.url?scp=79961132289&partnerID=8YFLogxK
U2 - 10.1039/C1SM05509G
DO - 10.1039/C1SM05509G
M3 - Journal articles
VL - 7
SP - 7304
EP - 7312
JO - Soft Matter
JF - Soft Matter
SN - 1744-6848
IS - 16
ER -