Spray-dried chitosan-metal microparticles for ciprofloxacin adsorption: Kinetic and equilibrium studies

Publikation: Beiträge in ZeitschriftenZeitschriftenaufsätzeForschungbegutachtet


  • Franceline Reynaud
  • Nicolas Tsapis
  • Michel Deyme
  • Tibiriça G. Vasconcelos
  • Claire Gueutin
  • Sílvia S. Guterres
  • Adriana R. Pohlmann
  • Elias Fattal
Chitosan, a natural polysaccharide obtained from chitin deacetylation, complexes with metal ions by coordination with the free electron pairs of amine groups. Based on this complexation mechanism, cross-linked chitosan-metal microparticles were prepared by spray drying using iron (II or III) or zinc ions and characterized in terms of size distribution and capacity to specifically adsorb ciprofloxacin. Chitosan-Zn(II) and chitosan-Fe(III) microparticles appear to adsorb more ciprofloxacin than plain chitosan or chitosan-Fe(II) microparticles. Adsorption isotherms for CH and CH–Fe(II) microparticles can be fitted by a single logarithm model (slope 1) with one ciprofloxacin per adsorption site, whereas for CH–Fe(II) and CH–Zn(II) microparticles, isotherms are bilogarithmic with an initial slope of 2, suggesting that a single adsorption site can bind two molecules of ciprofloxacin. In addition, the pseudo second order kinetic model fits well experimental data, proving that adsorption is mediated by a chemical reaction. CH–Fe(II) and CH–Zn(II) appear very promising for drug elimination, either from hospital waste water or from the gastrointestinal tract to prevent the emergence of antibiotic resistance.
ZeitschriftSoft Matter
Seiten (von - bis)7304-7312
Anzahl der Seiten9
PublikationsstatusErschienen - 21.08.2011