Recent research suggests that stereotypes are not only applied to social groups but also to the physical spaces that social groups inhabit. We present three experiments investigating space-focused stereotype content and valence regarding immigrant and non-immigrant neighbourhoods. In Study 1a (N = 198), a pre-registered online experiment, we observed that participants associate more negative characteristics with immigrant neighbourhoods than with middle-class neighbourhoods. Whereas they imagined immigrant neighbourhoods as crime-ridden, dirty and dangerous, they imagined middle-class neighbourhoods to be quiet, clean and safe. Furthermore, whereas stereotype valence regarding immigrant neighbourhoods was negative, stereotype valence regarding middle-class neighbourhoods was positive, suggesting large effects. These results were replicated in Study 1b (N = 274), examining stereotypes of immigrant versus majority-German neighbourhoods. In Study 2 (N = 209), a pre-registered online experiment, we observed that space-focused stereotypes were more negative when cultural stereotypes rather than personal beliefs were assessed. Exploratory analyses revealed that, compared with majority-German neighbourhoods, participants imagined immigrant neighbourhoods to be lower in socioeconomic status and also reported feeling less psychologically connected to these neighbourhoods, regardless of whether space-focused stereotypes were personally endorsed or not. Lastly, a mega-analysis across studies suggested that effects of stereotypes of immigrant in comparison to non-immigrant places were very large (d_s = 1.70). Together, the present findings indicate that mere differences in descriptions of places with reference to their demographic composition are sufficient to elicit large differences in associated stereotype content and valence.