Deactivation and transformation products in biodegradability testing of ß-lactams amoxicillin and piperacillin

Publikation: Beiträge in ZeitschriftenZeitschriftenaufsätzeForschungbegutachtet

Authors

Antibiotics have increasingly been detected in effluents and the environment. However, information on the degree of deactivation and mineralization, and the nature of possible formed dead-end transformation products is scarce but desirable for proper risk assessment. An important group of antibiotics is the ß-lactams. We studied the transformation of the closely structurally related ß-lactams piperacillin and amoxicillin in two OECD biodegradability batch tests. None of the antibiotics was biodegraded in the closed bottle test (CBT). However, primary abiotic elimination as monitored by HPLC-UV-VIS was 20% and 100% in the CBT within 14 days, respectively. With HPLC-UV-VIS and ion trap LC-MS/MS primary elimination was shown to be more than 94% for both antibiotics within seven days in the Zahn-Wellens test (ZWT). Both compounds were deactivated by hydrolysis. For piperacillin, a dead-end transformation product resulted after hydrolysis of the ß-lactam ring. For amoxicillin full mineralization of the transformation products was observed. © 2008 Elsevier Ltd. All rights reserved.
OriginalspracheEnglisch
ZeitschriftChemosphere
Jahrgang75
Ausgabenummer3
Seiten (von - bis)347-354
Anzahl der Seiten8
ISSN0045-6535
DOIs
PublikationsstatusErschienen - 04.2009
Extern publiziertJa

DOI

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