Deactivation and transformation products in biodegradability testing of ß-lactams amoxicillin and piperacillin

Publikation: Beiträge in ZeitschriftenZeitschriftenaufsätzeForschungbegutachtet

Standard

Deactivation and transformation products in biodegradability testing of ß-lactams amoxicillin and piperacillin. / Längin, Andreas; Alexy, Radka; König, Armin et al.
in: Chemosphere, Jahrgang 75, Nr. 3, 04.2009, S. 347-354.

Publikation: Beiträge in ZeitschriftenZeitschriftenaufsätzeForschungbegutachtet

Harvard

APA

Vancouver

Längin A, Alexy R, König A, Kümmerer K. Deactivation and transformation products in biodegradability testing of ß-lactams amoxicillin and piperacillin. Chemosphere. 2009 Apr;75(3):347-354. doi: 10.1016/j.chemosphere.2008.12.032

Bibtex

@article{5947d03109e2405e8807fca05ce03400,
title = "Deactivation and transformation products in biodegradability testing of {\ss}-lactams amoxicillin and piperacillin",
abstract = "Antibiotics have increasingly been detected in effluents and the environment. However, information on the degree of deactivation and mineralization, and the nature of possible formed dead-end transformation products is scarce but desirable for proper risk assessment. An important group of antibiotics is the {\ss}-lactams. We studied the transformation of the closely structurally related {\ss}-lactams piperacillin and amoxicillin in two OECD biodegradability batch tests. None of the antibiotics was biodegraded in the closed bottle test (CBT). However, primary abiotic elimination as monitored by HPLC-UV-VIS was 20% and 100% in the CBT within 14 days, respectively. With HPLC-UV-VIS and ion trap LC-MS/MS primary elimination was shown to be more than 94% for both antibiotics within seven days in the Zahn-Wellens test (ZWT). Both compounds were deactivated by hydrolysis. For piperacillin, a dead-end transformation product resulted after hydrolysis of the {\ss}-lactam ring. For amoxicillin full mineralization of the transformation products was observed. {\textcopyright} 2008 Elsevier Ltd. All rights reserved.",
keywords = "Chemistry, Closed Bottle Test, HPLC-UV-VIS, LC-MS, MS, mineralization, Zahn-Wellens Test, TRANSFORMATION, TRANSFORMATION PRODUCTS, Transformation product, PRODUCTS, PRODUCT, biodegradability, Beta-Lactam, Amoxicillin, Piperacillin",
author = "Andreas L{\"a}ngin and Radka Alexy and Armin K{\"o}nig and Klaus K{\"u}mmerer",
year = "2009",
month = apr,
doi = "10.1016/j.chemosphere.2008.12.032",
language = "English",
volume = "75",
pages = "347--354",
journal = "Chemosphere",
issn = "0045-6535",
publisher = "Elsevier Ltd",
number = "3",

}

RIS

TY - JOUR

T1 - Deactivation and transformation products in biodegradability testing of ß-lactams amoxicillin and piperacillin

AU - Längin, Andreas

AU - Alexy, Radka

AU - König, Armin

AU - Kümmerer, Klaus

PY - 2009/4

Y1 - 2009/4

N2 - Antibiotics have increasingly been detected in effluents and the environment. However, information on the degree of deactivation and mineralization, and the nature of possible formed dead-end transformation products is scarce but desirable for proper risk assessment. An important group of antibiotics is the ß-lactams. We studied the transformation of the closely structurally related ß-lactams piperacillin and amoxicillin in two OECD biodegradability batch tests. None of the antibiotics was biodegraded in the closed bottle test (CBT). However, primary abiotic elimination as monitored by HPLC-UV-VIS was 20% and 100% in the CBT within 14 days, respectively. With HPLC-UV-VIS and ion trap LC-MS/MS primary elimination was shown to be more than 94% for both antibiotics within seven days in the Zahn-Wellens test (ZWT). Both compounds were deactivated by hydrolysis. For piperacillin, a dead-end transformation product resulted after hydrolysis of the ß-lactam ring. For amoxicillin full mineralization of the transformation products was observed. © 2008 Elsevier Ltd. All rights reserved.

AB - Antibiotics have increasingly been detected in effluents and the environment. However, information on the degree of deactivation and mineralization, and the nature of possible formed dead-end transformation products is scarce but desirable for proper risk assessment. An important group of antibiotics is the ß-lactams. We studied the transformation of the closely structurally related ß-lactams piperacillin and amoxicillin in two OECD biodegradability batch tests. None of the antibiotics was biodegraded in the closed bottle test (CBT). However, primary abiotic elimination as monitored by HPLC-UV-VIS was 20% and 100% in the CBT within 14 days, respectively. With HPLC-UV-VIS and ion trap LC-MS/MS primary elimination was shown to be more than 94% for both antibiotics within seven days in the Zahn-Wellens test (ZWT). Both compounds were deactivated by hydrolysis. For piperacillin, a dead-end transformation product resulted after hydrolysis of the ß-lactam ring. For amoxicillin full mineralization of the transformation products was observed. © 2008 Elsevier Ltd. All rights reserved.

KW - Chemistry

KW - Closed Bottle Test

KW - HPLC-UV-VIS

KW - LC-MS

KW - MS

KW - mineralization

KW - Zahn-Wellens Test

KW - TRANSFORMATION

KW - TRANSFORMATION PRODUCTS

KW - Transformation product

KW - PRODUCTS

KW - PRODUCT

KW - biodegradability

KW - Beta-Lactam

KW - Amoxicillin

KW - Piperacillin

UR - http://www.scopus.com/inward/record.url?scp=63049132466&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/56580700-4f62-311e-b176-ea3ba7265174/

U2 - 10.1016/j.chemosphere.2008.12.032

DO - 10.1016/j.chemosphere.2008.12.032

M3 - Journal articles

C2 - 19171362

VL - 75

SP - 347

EP - 354

JO - Chemosphere

JF - Chemosphere

SN - 0045-6535

IS - 3

ER -

DOI

Zuletzt angesehen

Aktivitäten

  1. Kultur und Tourismus - Tourismusregion Elbe – Vielfältige Chancen zur Steigerung der Wirtschaftskraft. Elbeschifffahrtstag
  2. Nachhaltige Entwicklung und gesellschaftliche Partizipation aus der Perspektive kulturtheoretischer Handlungserklärungen
  3. Wer bist du – & wenn ja, wie viele? Zur Konstruktion & Verhandlung von nationaler Identität in Migrationsgesellschaft & Schule
  4. 11th Annual Colloquium of the International Association of Hydro-Environment Research and Engineering-Baden-Württemberg - 2010
  5. (De-)Thematisierung von Intersektionalität in der außerschulischen Bildungsarbeit für, mit und von ‚Geflüchtete(n)‘ in der Türkei.
  6. Die Konstruktion von ‚bildungsfernen Familien (mit Migrationshintergrund)‘ im Post-Pisa-Diskurs um ‚herkunftsbedingte Disparitäten‘.
  7. Szenarien zu den Konsequenzen des soziodemographischen Wandels für den Tourismus - Ein prozess- und praxisorientierter Ansatz.
  8. 4500 Kartoffelsorten – ein Schatz für die Zukunft. Biologische Vielfalt als Voraussetzung für eine zukunftsfähige Entwicklung
  9. Regieren durch Eltern: (Neue) schulische und migrationsgesellschaftliche Ausschlüsse im Kontext neoliberaler Gouvernementalität.
  10. Verhandlungen von Differenz und Zugehörigkeit an Berliner Schulen im Spiegel einer Ökonomisierung von Migration und Bildung.
  11. 4th International Annual Conference of the International Association of Teachers of English as a Foreign Language - IATEFL 2013
  12. Verhandlungen von Bildungsausschlüssen und -zugängen von schutzbedürftigen Kindern und Jugendlichen im europäischen Grenzregime
  13. proDUO – Jobsharing als Element des akademischen Personalmanagements von promovierten MitarbeiterInnen an deutschen Hochschulen