Deactivation and transformation products in biodegradability testing of ß-lactams amoxicillin and piperacillin

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Authors

Antibiotics have increasingly been detected in effluents and the environment. However, information on the degree of deactivation and mineralization, and the nature of possible formed dead-end transformation products is scarce but desirable for proper risk assessment. An important group of antibiotics is the ß-lactams. We studied the transformation of the closely structurally related ß-lactams piperacillin and amoxicillin in two OECD biodegradability batch tests. None of the antibiotics was biodegraded in the closed bottle test (CBT). However, primary abiotic elimination as monitored by HPLC-UV-VIS was 20% and 100% in the CBT within 14 days, respectively. With HPLC-UV-VIS and ion trap LC-MS/MS primary elimination was shown to be more than 94% for both antibiotics within seven days in the Zahn-Wellens test (ZWT). Both compounds were deactivated by hydrolysis. For piperacillin, a dead-end transformation product resulted after hydrolysis of the ß-lactam ring. For amoxicillin full mineralization of the transformation products was observed. © 2008 Elsevier Ltd. All rights reserved.
Original languageEnglish
JournalChemosphere
Volume75
Issue number3
Pages (from-to)347-354
Number of pages8
ISSN0045-6535
DOIs
Publication statusPublished - 04.2009
Externally publishedYes

    Research areas

  • Chemistry - Closed Bottle Test, HPLC-UV-VIS, LC-MS, MS, mineralization, Zahn-Wellens Test, TRANSFORMATION, TRANSFORMATION PRODUCTS, Transformation product, PRODUCTS, PRODUCT, biodegradability, Beta-Lactam, Amoxicillin, Piperacillin

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