Prevalence of depression in cancer patients: a meta-analysis of diagnostic interviews and self-report instruments

Research output: Journal contributionsScientific review articlesResearch

Authors

  • A. M. H. Krebber
  • L. M. Buffart
  • G. Kleijn
  • I. C. Riepma
  • R. de Bree
  • C. R. Leemans
  • A. Becker
  • J. Brug
  • Annemieke Van Straten
  • Pim Cuijpers
  • Irma M. Verdonck-de Leeuw

Objective We aimed to investigate the prevalence of depression in cancer patients assessed by diagnostic interviews and self-report instruments, and to study differences in prevalence between type of instrument, type of cancer and treatment phase. Methods A literature search was conducted in four databases to select studies on the prevalence of depression among adult cancer patients during or after treatment. A total of 211 studies met the inclusion criteria. Pooled mean prevalence of depression was calculated using Comprehensive Meta-Analysis. Results Hospital Anxiety and Depression Scale - depression subscale (HADS-D) ≥ 8, HADS-D ≥11, Center for Epidemiologic Studies ≥ 16, and (semi-)structured diagnostic interviews were used to define depression in 66, 53, 35 and 49 studies, respectively. Respective mean prevalence of depression was 17% (95% CI = 16-19%), 8% (95% CI = 7-9%), 24% (95% CI = 21-26%), and 13% (95% CI = 11-15%) (p < 0.001). Prevalence of depression ranged from 3% in patients with lung cancer to 31% in patients with cancer of the digestive tract, on the basis of diagnostic interviews. Prevalence of depression was highest during treatment 14% (95% CI = 11-17%), measured by diagnostic interviews, and 27% (95% CI = 25-30%), measured by self-report instruments. In the first year after diagnosis, prevalence of depression measured with diagnostic interviews and self-report instruments were 9% (95% CI = 7-11%) and 21% (95% CI = 19-24%), respectively, and they were 8% (95% CI = 5-12%) and 15% (95% CI = 13-17%) ≥ 1 year after diagnosis. Conclusions Pooled mean prevalence of depression in cancer patients ranged from 8% to 24% and differed by the type of instrument, type of cancer and treatment phase. Future prospective studies should disentangle whether differences in prevalence of depression are caused by differences in the type of instrument, type of cancer or treatment phase.

Original languageEnglish
JournalPsycho-Oncology
Volume23
Issue number2
Pages (from-to)121-130
Number of pages10
ISSN1057-9249
DOIs
Publication statusPublished - 02.2014

DOI

Recently viewed

Publications

  1. Qualitative human error analysis in medicine
  2. Didaktik des Sachrechnens in der Grundschule
  3. Data-driven analyses of electronic text books
  4. Das Schaudern ist der Menschheit bestes Teil
  5. Empirical research on mathematical modelling
  6. The perceived fairness of layoffs in Germany
  7. § 289 c Inhalt der nichtfinanziellen Erklärung
  8. Pädagogische Theorien und pädagogische Praxis
  9. ADORE - Teaching Adolescent Struggling Readers
  10. Scripting a distance-learning university course
  11. Falsches Spiel. Die Grenzen eines Ressentiments
  12. Merkmale guter Evaluation und Selbstevaluation
  13. Determination of vapor-phase PAH in ambient air
  14. § 315 d Konzernerklärung zur Unternehmensführung
  15. European and national law in history and future
  16. Kommentierung von: Art. 49 EUV: Beitritt zur Union
  17. Das Empire, der Nordwesten und der Rest der Welt
  18. Das Konzept von Lesekompetenz in der DESI-Studie
  19. Hartz IV für von Misshandlung betroffene Frauen
  20. IGLU - Internationale Grundschul-Lese-Untersuchung
  21. Symbolische Formen und Identitätskonstruktionen
  22. Kommentierung von Art. 53 EUV: Unbegrenzte Geltung
  23. Understanding the Dark Side of Costly Punishment
  24. Bildung, Sozialisation und soziale Ungleichheiten
  25. Kommunikation und Bildung – dem Klima auf der Spur
  26. Medienbiografie und Familie – Jugendliche erzählen
  27. Media Freedom and the Escalation of State Violence
  28. Auswahlbibliografie zur Kinder- und Jugendliteratur
  29. Regulierung der Abschlussprüfung nach dem FISG-RegE
  30. The relation of mindfulness and prosocial behavior
  31. A family member's death increases religious activity
  32. Professionswissen in den Naturwissenschaften (ProwiN)
  33. Wirkung von Lehrerfortbildungen auf Lehrerexpertise
  34. Patient-reported outcomes in rehabilitation research
  35. Mit psychischer Gesundheit zur guten Ganztagsschule