Element distribution in the corrosion layer and cytotoxicity of alloy Mg-10Dy during in vitro biodegradation

Research output: Journal contributionsJournal articlesResearchpeer-review

Authors

  • Lei Yang
  • Norbert Hort
  • Daniel Laipple
  • Daniel Höche
  • Yuanding Huang
  • Karl Ulrich Kainer
  • Regine Willumeit
  • Frank Feyerabend

The present work investigates the corrosion behaviour, the element distribution in the corrosion layer and the cytocompatibility of alloy Mg-10Dy. The corrosion experiments were performed in a cell culture medium (CCM) under cell culture conditions close to the in vivo environment. The element distribution on the surface as well as in cross-sections of the corrosion layer was investigated using scanning electron microscopy, energy-dispersive X-ray analysis, X-ray photoelectron spectroscopy and X-ray diffraction. The cytocompatibility of alloy Mg-10Dy with primary human osteoblasts was evaluated by MTT, cell adhesion and live/dead staining tests. The results show that the corrosion layer was enriched in Dy, while the P and Ca content gradually decreased from the surface to the bottom of the corrosion layer. In addition, large amounts of MgCO3·3H2O formed in the corrosion layer after 28 days immersion. Both extracts and the Dy-enriched corrosion layer of alloy Mg-10Dy showed no cytotoxicity to primary human osteoblasts.

Original languageEnglish
JournalActa Biomaterialia
Volume9
Issue number10
Pages (from-to)8475-8487
Number of pages13
ISSN1742-7061
DOIs
Publication statusPublished - 11.2013
Externally publishedYes

    Research areas

  • Cytocompatibility, Element distribution, In vitro corrosion, Mg-10Dy alloy
  • Engineering

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