Food waste valorisation is currently at the core of discussions and development of future economic models which, allied to the application of green and sustainable technologies, offers a viable alternative to shift industrial practices towards a circular bioeconomy. The feasibility and technological possibilities based on an integrated mango waste biorefinery concept, focusing on the extraction of bioactive compounds, are discussed in this paper. Additionally, a statistically robust methodology is presented as a green approach to optimise the variables of a sustainable, low time and energy consumption extraction technique (homogenizer-assisted extraction). Maximum concentrations of the bioactive compounds were obtained in similar values of parameters ethanol/water concentration (67.73 and 70.11 %), sample/solvent ratio (29.33 and 28.17 %) and time (4.47 and 5.00 min) for mangiferin (354.4 mg/kg DW) and hyperoside (258.7 mg/kg DW), respectively. These results demonstrated the efficiency of the proposed green and sustainable method to obtain bioactive compounds from a very common and significant tropical fruit waste in Brazil, based on an integrated mango biorefinery concept.